StressMarq/YM-08/SIH-122-10MG/10-mg
商品编号：
SIH-122-10MG
市场价：
¥3300.00
美元价：
1980.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | YM-08 |
| Description | Hsp70Inhibitor |
| Purity | >99%(HPLC) |
| MolecularFormula | C19H17N3OS2 |
| MolecularWeight | 367.49 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO |
| Source | Synthetic |
| Appearance | Yellow-orangesolid |
| SMILES | O=C2C(SC(=Cc1ncccc1)N2CC)=C3Sc4ccccc4N3C |
| SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection |
| CiteThisProduct | YM-08(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-122) |
BIOLOGicalDescription
| AlternativeNames | (2Z,5E)-3-ethyl-5-(3-methyl-1,3-benzothiazol-2-ylidene)-2-(pyridin-2-ylmethylidene)-1,3-thiazolidin-4-one,YM8,YM08 |
| ResearchAreas | Cancer,HeatShock |
| ScientificBackground | YM-08isaHeatShockProtein70(Hsp70)inhibitorthatisblood-brainbarrierpermeable.YM-08isaneutralderivativeoftheHsp70inhibitorMKT-077.MKT-077reducestaulevelsincellularmodels,butitdoesn′tpenetratethebloodbrainbarrier.AlthoughYM-08wassomewhatlesseffectivethanMKT-077inanti-tauandanticancerassays,itselectivelyreducedpathogenictauinbrainslices,whichMKT-077didnot.FurThermore,YM-08wasnotretainedinthekidneyleADIngonetospeculatethatitwouldnothavethenephrotoxicitythatwasaproblemforMKT-077inclinicaltrials.LookingformoreinformationonHSP70?VisitournewHSP70ScientificResourceGuideathttp://www.HSP70.com. |
| References | 1.Miyata,Y.etal.2013ACSChemicalNeuroscienceJun19;4(6):930-9.doi:10.1021/cn300210g |
ProductImages
ChemicalstructureofYM-08(SIH-122),aHsp70Inhibitor.CAS#:N/A.MolecularFormula:C19H17N3OS2.MolecularWeight:367.49g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
