StressMarq/YM-01/SIH-121-25MG/25-mg
商品编号：
SIH-121-25MG
市场价：
¥6600.00
美元价：
3960.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | YM-01 |
| Description | Hsp70Inhibitor |
| Purity | >98%(HPLC) |
| CASNo. | 409086-68-6 |
| MolecularFormula | C20H20ClN3OS2 |
| MolecularWeight | 417.97 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | Solubleinwarmwater(2mg/ml) |
| Source | Synthetic |
| Appearance | Orangeredsolid |
| SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection |
| CiteThisProduct | YM-01(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-121) |
BIOLOGicalDescription
| AlternativeNames | 2-((Z)-((E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-iumchloride;YM-1 |
| ResearchAreas | Cancer,HeatShock |
| ScientificBackground | YM-01isanallostericHsp70inhibitor.ItbindswithinHsp70"snucleotidebindingdomain,adjacenttoATP/ADPbindingpocket.ItinhibitsJ-stimulatedATPturnoverrate.ItblocksHsc70-bag1interactionbothinvitroandinvivoandenhancesbindingofHsp70tomisfoldedproteins.Itreducestaulevelsintau-overexpressedHeLacells,endogenoustauinneuroblastomacells,andendogenoustauinprimaryneuronfromrTg4510mice,withEC50"soflowmicromolar.Itrecoverslong-termpotentiationdeficitsinbrainslicesfromrTg4510mice.Italsohasanti-canceractivity,withanEC50valueoflowmicromolaragainstseveralcancercelllines.ItdestABIlizesoncoproteinsincells,includingAktandRaf-1.LookingformoreinformationonHSP70?VisitournewHSP70ScientificResourceGuideathttp://www.HSP70.com. |
| References | 1.Wangetal.,2013NatureChem.Biol.9:112-118. 2.Abisambraetal.,2013Biol.Psychiatry,74:367-374. 3.Korenetal.PLoSOne7:e35566. 4.Morishimaetal.2011Biochemistry.50:7146. 5.Davisetal.2012J.Immunol.189:4488. |
ProductImages
ChemicalstructureofYM-01(SIH-121),aHsp70Inhibitor.CAS#:409086-68-6.MolecularFormula:C20H20ClN3OS2.MolecularWeight:417.97g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
