StressMarq/Xanthohumol/SIH-370-10MG/10-mg
商品编号：
SIH-370-10MG
市场价：
¥3400.00
美元价：
2040.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| Product Name | Xanthohumol |
| Description | Autophagy inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 6754-58-1 |
| Molecular Formula | C21H22O5 |
| Molecular Weight | 354.4 |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (35 mg/ml) or Ethanol (35 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | CC(=CCC1=C(C(=C(C=C1O)OC)C(=O)/C=C/C2=CC=C(C=C2)O)O)C |
| InChI | InChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+ |
| InChIKey | ORXQGKIUCDPEAJ-YRNVUSSQSA-N |
| Safety Phrases | Classification: Toxic Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H317 May cause an allergic skin reaction. H400 Very toxic to aquatic life. Precautionary Phrases: P273 Avoid release to the environment. P280 Wear protective gloves. |
| Cite This Product | Xanthohumol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-370) |
Biological Description
| Alternative Names | (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one |
| Research Areas | Cancer, Autophagy |
| PubChem ID | 639665 |
| Scientific Background | Xanthohumol is a valosin-containing protein (VCP) inhibitor which binds to the N-domain of VCP, suppressing function and impairing autophagosome maturation (1). It also inhibits growth of a wide variety of human cancer cell lines by inhibiting proliferation and inducing apoptosis (2). |
| References |
1. Sasazawa Y., et al. (2012) ACS Chem Biol. 7(5): 892-900. 2. Vene R., et al. (2012) Mol. Med. 18: 1292. |
Product Images
Chemical structure of Xanthohumol (SIH-370), a Autophagy inhibitor. CAS #: 6754-58-1. Molecular Formula: C21H22O5. Molecular Weight: 354.4 g/mol.
Product Citations (0)
Currently there are no citations for this product.
品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
