StressMarq/Wortmannin/SIH-392-5MG/5-mg
商品编号：
SIH-392-5MG
市场价：
¥4300.00
美元价：
2580.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Wortmannin |
| Description | Autophagyinhibitor |
| Purity | >98% |
| CASNo. | 19545-26-7 |
| MolecularFormula | C23H24O8 |
| MolecularWeight | 428.44 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO(50mg/ml),methanol(5mg/ml)or100%ethanol(25mg/ml). |
| Source | Synthetic |
| Appearance | Whitetooff-whitesolid. |
| SMILES | [[email protected]@]15(C4=C(C(C2=C1[[email protected]@H](C[[email protected]]3([[email protected]]2CCC3=O)C)OC(=O)C)=O)OC=C4C(O[[email protected]@H]5COC)=O)C |
| InChI | InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1 |
| InChIKey | QDLHCMPXEPAAMD-QAIWCSMKSA-N |
| SafetyPhrases | Classification:D1A-VeryToxicMaterialCausingImmediateandSeriousToxicEffects,Highlytoxicbyingestion,HighlytoxicbyskinabsorptionSafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H300+H310-FatalifswallowedorincontactwithskinH330-Fatalifinhaled.Precautionarystatements:P260-Donotbreathedust/fume/gas/mist/vapours/spray.P264-Washhandsthoroughlyafterhandling.P280-Wearprotectivegloves/protectiveclothing.P284-Wearrespiratoryprotection.P302+P350-IFONSKIN:Gentlywashwithplentyofsoapandwater.P310-ImmediatelycallaPOISONCENTERordoctor/physician. |
| CiteThisProduct | Wortmannin(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-392) |
BIOLOGicalDescription
| AlternativeNames | SL-2052,KY12420 |
| ResearchAreas | Cancer,Autophagy |
| PubChemID | 312145 |
| ScientificBackground | WortmanninisasteroidmetabolitefromthefungiPenicilliumfuniculosum.ItspecificallyandirreversIBLyinhibitsphosphatidylinositol3-kinase(PI3-K).Thisinturnhasbeenshowntoinhibitthemetaboliceffectsofinsulin,yettheinsulinreceptorkinaseactivityisnotaltered.BecausePI3-Kisinvolvedinmembranetrafficking,andmembranetraffickingisimportantinautophagy,Wortmanninalsoinhibitsautophagy. |
| References | 1.PowisG.,etal.(1994).CancerRes.54(9):2419-23. 2.HazekiO.,etal.(1996).JLipidMediatCellSignal.14(1-3):259-61. 3.LeeA.,etal.(1995).FEBSLett.361(1):51-4. 4.BlommaartE.F.,etal.(1997).EurJBiochem.243(1-2):240-6. |
ProductImages
ChemicalstructureofWortmannin(SIH-392),aAutophagyinhibitor.CAS#:19545-26-7.MolecularFormula:C23H24O8.MolecularWeight:428.44g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
