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当前位置： 首页 > 产品中心 > Electrophoretic_buffer > StressMarq/抗VEGF受体1抗体/SPC-1210D-HRP/100-µl
商品详细StressMarq/抗VEGF受体1抗体/SPC-1210D-HRP/100-µl
StressMarq/抗VEGF受体1抗体/SPC-1210D-HRP/100-µl
StressMarq/抗VEGF受体1抗体/SPC-1210D-HRP/100-µl
商品编号： SPC-1210D-HRP
市场价： ¥6600.00
美元价： 3960.00
产地： 美国(厂家直采)
公司：
产品分类： 电泳缓冲液
公司分类： Electrophoretic_buffer
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

Product Name VEGF Receptor 1 Antibody
Description

Rabbit Anti-Human VEGF Receptor 1 Polyclonal

Species Reactivity Human, Mouse
Applications WB, AM
Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen Synthetic peptide of human VEGF Receptor 1 (AA143-158)
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Peptide Affinity Purified
Clonality Polyclonal
Specificity Detects 151 kDa.
Cite This Product StressMarq Biosciences Cat# SPC-1210, RRID: AB_2712161
Certificate of Analysis A 1:250 dilution of SPC-1210 was sufficient for detection of VEGF Receptor 1 in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names EC 2.7.10.1 Antibody, FLT 1 Antibody, FLT Antibody, Flt-1 Antibody, FLT1 Antibody, Fms like tyrosine kinase 1 Antibody, Fms related tyrosine kinase 1 Antibody, Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) Antibody, Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor Antibody, Fms-like tyrosine kinase 1 Antibody, FRT Antibody, Soluble VEGF receptor 1 14 Antibody, Soluble VEGFR1 variant 2 Antibody, Soluble VEGFR1 variant 21 Antibody, Tyrosine protein kinase FRT Antibody, Tyrosine protein kinase receptor FLT Antibody, Tyrosine-protein kinase FRT Antibody, Tyrosine-protein kinase receptor FLT Antibody, Vascular endothelial growth factor receptor 1 Antibody, Vascular endothelial growth factor vascular permeability factor receptor Antibody, Vascular permeability factor receptor 1 Antibody, Vascular permeability factor receptor Antibody, VEGFR 1 Antibody, VEGFR-1 Antibody, VEGFR1 Antibody, VGFR1_HUMAN Antibody
Cellular Localization Cytoplasm, Cell membrane, Secreted
Accession Number NP_002010
Gene ID 2321
Swiss Prot P17948
Scientific Background FLT1 is a receptor-tyrosine kinase that is activated upon binding with VEGF-A, VEGF-B and PGF. It plays an important role in the development of embryonic vasculature, and as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. However, it can promote PGF-mediated endothelial cell proliferation, survival and angiogenesis in adults, although this seems to be cell-type specific. It also contributes to cancer cell survival, proliferation, migration, and invasion, as well as tumour angiogenesis, metastasis, and recruitment of tumour-infiltrating macrophages. It has a very high affinity for VEGF-A and may function as a negative regulator of VEGF-A signalling by limiting the amount of free VEGF-A and preventing its binding to KDR. Isoforms lacking a transmembrane domain may function as decoy receptors for VEGF-A. Furthermore, it mediates phosphorylation of PI3K, leading to activation of the downstream signalling pathway, as well as mediating the activation of the MAPK signalling pathway, and of the Akt/PKB signalling pathway.

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HRP (Horseradish peroxidase)

Properties:

  • Enzymatic activity is used to amplify weak signals and increase visibility of a target
  • Readily combines with hydrogen peroxide (H2O2) to form HRP-H2O2 complex which can oxidize various hydrogen donors
  • Catalyzes the conversion of:
    • Chromogenic substrates (e.g. TMB, DAB, ABTS) into coloured products
    • Chemiluminescent substrates (e.g. luminol and isoluminol) into light emitting products via enhanced chemiluminescence (ECL)
    • Fluorogenic substrates (e.g. tyramine, homovanillic acid, and 4-hydroxyphenyl acetic acid) into fluorescent products
  • High turnover rate enables rapid generation of a strong signal
  • 44 kDa glycoprotein
  • Extinction coefficient: 100 (403 nm)
  • Applications: Western blot, immunohistochemistry, and ELISA

HRP Datasheet

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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