StressMarq/U-0126/SIH-380-25MG/25-mg
商品编号：
SIH-380-25MG
市场价：
¥12880.00
美元价：
7728.00
产品分类：
电泳缓冲液
公司分类：
Electrophoretic_buffer
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | U-0126 |
| Description | MEKinhibitor |
| Purity | >98% |
| CASNo. | 109511-58-2 |
| MolecularFormula | C18H16N6S2 |
| MolecularWeight | 380.5 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO(>10mg/ml),100%ethanol(2mg/ml) |
| Source | Synthetic |
| Appearance | Whitesolid |
| SMILES | C2=C(SC(/N)=C(/C(=C(SC1=CC=CC=C1N)N)C#N)C#N)C(=CC=C2)N |
| InChI | InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+ |
| InChIKey | DVEXZJFMOKTQEZ-JYFOCSDGSA-N |
| SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-Donotbreathedust.S24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection |
| CiteThisProduct | U-0126(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-380) |
BIOLOGicalDescription
| AlternativeNames | 1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butADIene |
| ResearchAreas | CellSignaling |
| PubChemID | 3006531 |
| ScientificBackground | U-0126isanovel,potentandselectiveMEKinhibitor(MEK1;IC50=72nM,MEK2;IC50=58nM).InhibitsAP-1transcriptionactivity.Blockstheproductionofinflammatorycytokinesandmatrixmetalloproteinases.Bindingofextracellulargrowthfactorstocellsurfacereceptorsoftenresultsinactivationofthemitogen-activatedproteinkinase(MAPK).MAPKisregulatedbyMAPKkinase,alsocalledMEK.DeprivationofgrowthfactorsduringcellcultureorintracellularMEKinhibitionleadstoinhibitionofproliferationandapoptoticcelldeath.NBlanketal.(2002)haveshownthatU0126,acommonusedMEKinhibitorandcompoundthatitselfhasnointrinsicfluorescenceinvitrobutdevelopsanintensivefluorescenceduringcellculturewhichcanbeobservedinallfluorescencechannelswithpredominanceintheFL1channel(525nm). |
| References | 1.DunciaJ.V.,eta.l(1998)Bioorg.Med.Chem.Lett.8(20):2839-44. 2.FavataM.F.,etal.(1998)J.Biol.Chem.273(29):18623-32. 3.DaviesS.P.,etal.(2000)Biochem.J.351(Pt1):95-105. 4.NamuraS.,etal.(2001)Proc.Natl.Acad.Sci.U.S.A.98(20):11569-74. |
ProductImages
ChemicalstructureofU-0126(SIH-380),aMEKinhibitor.CAS#:109511-58-2.MolecularFormula:C18H16N6S2.MolecularWeight:380.5g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
