StressMarq/Trichostatin A/SIH-254-1MG/1-mg
商品编号：
SIH-254-1MG
市场价：
¥2520.00
美元价：
1512.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| Product Name | Trichostatin A |
| Description | HDAC inhibitor |
| Purity | >98% |
| CAS No. | 58880-19-6 |
| Molecular Formula | C17H22N2O3 |
| Molecular Weight | 302.37 |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 10 mM in ethanol and to 50 mM in DMSO |
| Source | Synthetic |
| Appearance | Beige Solid |
| SMILES | C[[email protected]](/C=C(C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C |
| InChI | InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+ |
| InChIKey | RTKIYFITIVXBLE-WKWSCTOISA-N |
| Safety Phrases | Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed R68 - Possible risk of irreversible effects Hazard Phrases: H302-H312-H315-H317-H319-H332-H335 Precautionary Phrases: P261-P280-P305 + P351 + P338 |
| Cite This Product | Trichostatin A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-254) |
Biological Description
| Alternative Names | (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide |
| Research Areas | Cancer, Apoptosis, Cancer Growth Inhibitors, HDAC Inhibitors |
| PubChem ID | 444732 |
| Scientific Background | Trichostatin A is an antifungal and selectively inhibits the class I and II mammalian histon deacetlyase families of enzymes (1). TSA inhibits the eukayotic cell cycle during the beginning of the growth stage. It can be used to alter gene expression but interfering with the removal of acetyl groups thereby altering the ability of DNA transcription factors to access the DNA inside chromatin (2). It also has anti-cancer properties (3). |
| References |
1. Vanhaecke T., Papeleu P., Elaut G., Rogiers V. (2004) Curr Med Chem. 11(12): 1629-1643. 2. Yoshida, et al. (1990) J Biol Chem. 165: 17174. 3. Drummond D.C., et al. (2005) Annu Rev Pharmacol Toxicol. 45: 495-528. |
Product Images
Chemical structure of Trichostatin A (SIH-254), a Histone deacetylase inhibitor. CAS #: 58880-19-6. Molecular Formula: C17H22N2O3. Molecular Weight: 302.37 g/mol.
Product Citations (0)
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
