应激MARQ/TKD肽（Hsp70肽）/SIH-118A/1-mg
商品编号：
SIH-118A
市场价：
¥4420.00
美元价：
2652.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | TKDPeptide(Hsp70Peptide) |
| Description | Hsp70Peptide |
| Purity | >98% |
| MolecularFormula | TKDNNLLGRFELSG |
| MolecularWeight | 1363 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Activator |
| Solubility | Inaqueoussolution |
| Source | Synthetic |
| Appearance | Solid |
| SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection |
| CiteThisProduct | TKDPeptide(Hsp70Peptide)(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-118) |
BIOLOGicalDescription
| ResearchAreas | Cancer,HeatShock |
| ScientificBackground | Hsp70genesencodeabundantheat-inducIBLe70-kDahsps(hsp70s).Inmosteukaryoteshsp70genesexistaspartofamultigenefamily.Theyarefoundinmostcellularcompartmentsofeukaryotesincludingnuclei,mitochondria,chloroplasts,theendoplasmicreticulumandthecytosol,aswellasinbacteria.Thegenesshowahighdegreeofconservation,havingatleast5O%identity(1).TheN-terminaltwothirdsofhsp70saremoreconservedthantheC-terminalthird.Hsp70bindsATPwithhighaffinityandpossessesaweakATPaseactivitywhichcanbestimulatedbybindingtounfoldedproteinsandsyntheticpeptides(2).Whenhsc70(constitutivelyexpressed)presentinmammaliancellswastruncated,ATPbindingactivitywasfoundtoresideinanN-terminalfragmentof44kDawhichlackedpeptidebindingcapacity.PolypeptidebindingABIlitythereforeresidedwithintheCterminalhalf(3).ThestructureofthisATPbindingdomaindisplaysmultiplefeaturesofnucleotidebindingproteins(4).Heatshockprotein70hasalsobeenfoundtohaveahighdegreeofplasmamembranelocalizationintumourcelllines.Thisiscorrelatedwithincreasedsensitivitytolysismediatedbynaturalkiller(NK)cells.TheTKDpeptideisapartialhsp70sequence(TKDNNLLGRFELSG-aa.450-463)andhasidenticaleffectsonNKcellsasfull-lengthHsp70protein,beingabletostimulatenaturalkillercellsactivityatequivalentconcentrationstofull-lengthHsp70protein(5).IncubationofperipheralbloodlymphocytecellswithTKDpluslow-doseinterleukin2(IL-2)enhancesthecytolyticactivityofNKcellsagainstHsp70membrane-positivetumors,invitroandinvivo(6).LookingformoreinformationonHSP70?VisitournewHSP70ScientificResourceGuideathttp://www.HSP70.com. |
| References | 1.BoorsteinW.R.,ZiegelhofferT.&CraigE.A.(1993)J.Mol.Evol.38(1):1-17. 2.RothmanJ.(1989),Cell59:591-601. 3.DeLuca-Flahertyetal.(1990)Cell62:875-887. 4.BorkP.,SanderC.&ValenciaA.(1992)Proc.NatlAcad.Sci.USA89:7290-7294. 5.MulthoffG.,etal.(2001)CellStressChaperones6(4):337-344. 6.Krause,S.W.etal.(2004)Clin.CancerRes.10(11):3699-3707. |
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
