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当前位置： 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-THRB Antibody/SPC-1314D-ALP/100-µl
商品详细StressMarq/Anti-THRB Antibody/SPC-1314D-ALP/100-µl
StressMarq/Anti-THRB Antibody/SPC-1314D-ALP/100-µl
StressMarq/Anti-THRB Antibody/SPC-1314D-ALP/100-µl
商品编号： SPC-1314D-ALP
市场价： ¥5920.00
美元价： 3552.00
产地： 美国(厂家直采)
公司：
产品分类： 酸碱缓冲液
公司分类： acid_base_buffer_solution
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

Product Name THRB Antibody
Description

Rabbit Anti-Human THRB Polyclonal

Species Reactivity Human, Mouse, Rat
Applications WB, IHC, ELISA
Antibody Dilution WB (1:1000), IHC (1:100), ELISA (1:5000); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen Synthesized peptide derived from human Thyroid Hormone Receptor β antibody.
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Affinity Purified
Clonality Polyclonal
Isotype IgG
Specificity Detects ~42kDa, endogenous levels of total Thyroid Hormone Receptor β protein.
Cite This Product StressMarq Biosciences Cat# SPC-1314, RRID: AB_2713439
Certificate of Analysis A 1:1000 dilution of SPC-1314 was sufficient for detection of THRB in 10 µg of LOVO cell lysates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2 Antibody, C ERBA 2 Antibody, C ERBA BETA Antibody, c-erbA-2 Antibody, c-erbA-beta Antibody, ERBA 2 Antibody, ERBA BETA Antibody, ERBA2 Antibody, Erythroblastic leukemia viral (v erb a) oncogene homolog 2 avian Antibody, generalized resistance to thyroid hormone Antibody, GRTH Antibody, MGC126109 Antibody, MGC126110 Antibody, NR1A2 Antibody, Nuclear receptor subfamily 1 group A member 2 Antibody, Oncogene ERBA2 Antibody, PRTH Antibody, THB_HUMAN Antibody, THR1 Antibody, THRB 1 Antibody, THRB 2 Antibody, thrB Antibody, THRB1 Antibody, THRB2 Antibody, Thyroid hormone nuclear receptor beta variant 1 Antibody, Thyroid hormone receptor beta 1 Antibody, Thyroid hormone receptor beta 2 Antibody, Thyroid hormone receptor beta Antibody, Thyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian) Antibody
Cellular Localization Nucleus
Accession Number NP_000452.2
Gene ID 7068
Swiss Prot P10828
Scientific Background There are three forms of the thyroid hormone receptor designated alpha-1, beta-1 and beta-2 that are able to bind thyroid hormone. There are two TR-α receptor splice variants encoded by the THRA gene and two TR-β isoform splice variants encoded by the THRB gene. Thyroid hormone receptor β-1 operates as a hormone-dependent transcriptional regulator that binds DNA sequences and is activated by 3,5,3’-l-triiodothyronine (T3). Thyroid hormone receptor β-1 is important in vertebrate development, specifically in developing limbs and face. 9-cis-retinoic acid receptor (RXR) and retinoic acid receptor (RAR) receptor families are often associated with thyroid hormone receptor β-1 and form homodimers and heterodimers.
References 1. Flamant F et al. (2006) Pharmacol Rev 58 (4): 705–11.

Product Images

<p>Immunohistochemistry analysis using Rabbit Anti-THRB Polyclonal Antibody (SPC-1314). Tissue: Lung Carcinoma Tissue. Species: Human. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-THRB Polyclonal Antibody (SPC-1314) at 1:100. The image on the right is treated with the synthesized peptide.</p>

Immunohistochemistry analysis using Rabbit Anti-THRB Polyclonal Antibody (SPC-1314). Tissue: Lung Carcinoma Tissue. Species: Human. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-THRB Polyclonal Antibody (SPC-1314) at 1:100. The image on the right is treated with the synthesized peptide.

<p>Western blot analysis of Human LOVO cell lysates showing detection of ~42kDa THRB protein using Rabbit Anti-THRB Polyclonal Antibody (SPC-1314). Lane 1: Human LOVO cells. Lane 2: Human LOVO cells treated with the immunizing peptide. Primary Antibody: Rabbit Anti-THRB Polyclonal Antibody (SPC-1314) at 1:1000. Predicted/Observed Size: ~42kDa. Other Band(s): ~55kDa.</p>

Western blot analysis of Human LOVO cell lysates showing detection of ~42kDa THRB protein using Rabbit Anti-THRB Polyclonal Antibody (SPC-1314). Lane 1: Human LOVO cells. Lane 2: Human LOVO cells treated with the immunizing peptide. Primary Antibody: Rabbit Anti-THRB Polyclonal Antibody (SPC-1314) at 1:1000. Predicted/Observed Size: ~42kDa. Other Band(s): ~55kDa.

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AP (Alkaline Phosphatase)

Properties:

  • Broad enzymatic activity for phosphate esters of alcohols, amines, pyrophosphate, and phenols
  • Commonly used to dephosphorylate the 5’-termini of DNA and RNA to prevent self-ligation
  • Catalyzes the conversion of:
    • Chromogenic substrates (e.g. pNPP, naphthol AS-TR phosphate, BCIP) into coloured products
    • Fluorogenic substrates (e.g. 4-methylumbelliferyl phosphate) into fluorescent products
  • Molecular weight: 140 kDa
  • Applications: Western blot, immunohistochemistry, and ELISA

AP Datasheet

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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