StressMarq/Thiolutin/SIH-375-5MG/5-mg
商品编号：
SIH-375-5MG
市场价：
¥7800.00
美元价：
4680.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Thiolutin |
| Description | RNApolymeraseinhibitor |
| Purity | >98%(TLC);NMR(Conforms) |
| CASNo. | 87-11-6 |
| MolecularFormula | C8H8N2O2S2 |
| MolecularWeight | 228.3 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | MaybedissolvedinDMSO(15mg/ml) |
| Source | Synthetic |
| Appearance | Yellowpowder |
| SMILES | CC(=O)NC1=C2C(=CSS2)N(C1=O)C |
| InChI | InChI=1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h4H,1-2H3,(H,9,11) |
| InChIKey | MHMRAFONCSQAIA-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Danger.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionHazardPhrases:H300–FatalifswallowedH330–FatalifinhaledPrecautionaryPhrases:P260–Donotbreathedust/fume/gas/mist/vapours/sprayP301+P310IFSWALLOWED:ImmediatelycallaPOISONCENTERordoctor/physicianP405–Storelockedup |
| CiteThisProduct | Thiolutin(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-375) |
BIOLOGicalDescription
| AlternativeNames | N-(4,5-Dihydro-4-methyl-5-oxo-1,2-d¬ithiolo[4,3-b]pyrrol-6-yl)acetamide |
| ResearchAreas | CellSignaling,Epigenetics |
| PubChemID | 6870 |
| ScientificBackground | Thiolutinisasulfurantibiotic.Studiesshowthepotentialtranscriptionalinhibitiononyeastdegradation.BycalculatingthemRNAdecayratesoftranscriptionatdifferenttimesafterinhibition,itwasevidentthattheeffectofThiolutinonthevariousdegradationpathwaysofmRNAcompromisesthestABIlityofthemRNAandthemechanismofgeneexpression(1).InpharmacologyisknowntoinhibitendothelialcelladhesionbyperturbingHsp27interactionswithcomponentsoftheactinandintermediatefilamentCytoskeleton(2).Studiesshowntheinhibitionoftumorcell-inducedangionegesisinvivo,adhesionofendothelialcellstovitronectin(IC50=0.83µM)(3).Potentiallyinhibitsdevelopmentalangiogenesisinzebrafish(2).Cellpermeable.Activeinvivo.LookingformoreinformationonHSP27?VisitournewHSP27ScientificResourceGuideathttp://www.HSP27.com. |
| References | 1.PelechanoV.andPerez-OrtinJ.(2008)Yeast25:85-92. 2.JiaY.,etal.(2010)CellStressChaperones15:165. 3.MinamiguchiK.,etal.(2001)InternationalJ.Cancer.93:307. |
ProductImages
ChemicalstructureofThiolutin(SIH-375),aHSP27perturbingagent.CAS#:87-11-6.MolecularFormula:C8H8N2O2S2.MolecularWeight:228.3g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
