StressMarq/Thapsigargin/SIH-399-5MG/5-mg
商品编号：
SIH-399-5MG
市场价：
¥5580.00
美元价：
3348.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Thapsigargin |
| Description | Autophagyinhibitor |
| Purity | >95% |
| CASNo. | 67526-95-8 |
| MolecularFormula | C34H50O12 |
| MolecularWeight | 650.8 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO(20mg/ml),100%ethanol(20mg/ml)oracetone. |
| Source | Synthetic |
| Appearance | Colorlesswaxorwhitesolid. |
| SMILES | [[email protected]@H]13C(=C([[email protected]](OC(=O)C(=CC)/C)[[email protected]]1OC(=O)CCCCCCC)C)[[email protected]@H]2OC(=O)[[email protected]@](O)([[email protected]@]2(O)[[email protected]@H](OC(=O)CCC)C[[email protected]@]3(OC(=O)C)C) |
| InChI | InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b1 |
| InChIKey | IXFPJGBNCFXKPI-FSIHEZPISA-N |
| SafetyPhrases | Classification:D1A-VeryToxicMaterialCausingImmediateandSeriousToxicEffects,HighlyToxic,D2A-VeryToxicMaterialCausingOtherToxicEffects,Respiratorysensitiser,D2B-ToxicMaterialCausingOtherToxicEffects,Moderateskinirritant,ModerateeyeirritantSafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H315-Causesskinirritation.H319-Causesseriouseyeirritation.H334-Maycauseallergyorasthmasymptomsorbreathingdifficultiesifinhaled.H335-Maycauserespiratoryirritation.Precautionarystatements:P261-Avoidbreathingdust/fume/gas/mist/vapours/spray.P305+P351+P338-IFINEYES:Rinsecautiouslywithwaterforseveralminutes.Removecontactlenses,ifpresentandeasytodo.Continuerinsing.P342+P311-Ifexperiencingrespiratorysymptoms:CallaPOISONCENTERordoctor/physician. |
| CiteThisProduct | Thapsigargin(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-399) |
BIOLOGicalDescription
| AlternativeNames | (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yloctanoate |
| ResearchAreas | Cancer,Autophagy |
| PubChemID | 446378 |
| ScientificBackground | Thapsigarginisacell-permeableinhibitorofthesarco-endoplasmaticreticulumCa2+-ATPase(SERCA).ThisinhibitioncausesthereleaseofintracellularCa2+stores.Thapsigarginalsoinhibitsautophagy.ThisisduetotheinductionofandanERstressresponse,whichcausesdownstreameffectsthatincludeanaccumulationofautophagosomesinthecytosol.Theseintermediatestructuresnevermatureintoamphisomesandautolysosomes,andtheautophagyprocesscannotbecompleted. |
| References | 1.CanováN.K.,etal.(2007)CellBiolToxicol.23(5):337-54. 2.GanleyI.G.,etal.(2011)Autophagy.7(11):1397-9. 3.ChengY.,etal.(2013)Autophagy.9(2):208-19. |
ProductImages
ChemicalstructureofThapsigargin(SIH-399),aAutophagyinhibitor.CAS#:67526-95-8.MolecularFormula:C34H50O12.MolecularWeight:650.8g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
