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当前位置： 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-TGF beta 3 Antibody/SPC-1313D-HRP/100-µl
商品详细StressMarq/Anti-TGF beta 3 Antibody/SPC-1313D-HRP/100-µl
StressMarq/Anti-TGF beta 3 Antibody/SPC-1313D-HRP/100-µl
StressMarq/Anti-TGF beta 3 Antibody/SPC-1313D-HRP/100-µl
商品编号： SPC-1313D-HRP
市场价： ¥5800.00
美元价： 3480.00
产地： 美国(厂家直采)
公司：
产品分类： 酸碱缓冲液
公司分类： acid_base_buffer_solution
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

Product Name TGF beta 3 Antibody
Description

Rabbit Anti-Human TGF beta 3 Polyclonal

Species Reactivity Human, Mouse, Rat
Applications WB, IHC, ELISA
Antibody Dilution WB (1:1000), IHC (1:100), ELISA (1:10000); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen Synthesized peptide derived from human TGF β3.
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Affinity Purified
Clonality Polyclonal
Isotype IgG
Specificity Detects ~50kDa, endogenous levels of total TGF β3 protein.
Cite This Product StressMarq Biosciences Cat# SPC-1313, RRID: AB_2713421
Certificate of Analysis A 1:1000 dilution of SPC-1313 was sufficient for detection of TGF beta 3 in 10 µg of Cos7 cell lysates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names ARVD Antibody, ARVD1 Antibody, FLJ16571 Antibody, MGC105479 Antibody, MGC118722 Antibody, prepro-transforming growth factor beta-3 Antibody, RNHF Antibody, TGF beta 3 Antibody, TGF beta3 Antibody, TGF-beta-3 Antibody, TGFB 3 Antibody, Tgfb3 Antibody, TGFB3_HUMAN Antibody, transforming growth factor beta 3 Antibody, Transforming growth factor beta-3 Antibody
Cellular Localization Secreted
Accession Number NP_003230.1
Gene ID 7043
Swiss Prot P10600
Scientific Background Transforming growth factor beta-3 is a protein that in humans is encoded by the TGFB3 gene. It is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. TGFBR3 is extensively modified by glycosaminoglycan groups (GAG). TGF-β3 is believed to regulate molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate. This is caused by failure of epithelial cells in both sides of the developing palate to fuse.
References 1. Bandyopadhyay B et al. (2006) The Journal of Cell Biology 172 (7): 1093–105.
2. Herpin A et al. (2004) Developmental and Comparative Immunology 28 (5): 461–85.
3. Taya Y et al. (1999) Development 126 (17): 3869–79.
4. Dudas M et al. (2004) Developmental Biology 266 (1): 96–108.
5. Kaartinen V et al. (1995) Nature Genetics 11 (4): 415–21.

Product Images

<p>Immunohistochemistry analysis using Rabbit Anti-TGF beta 3 Polyclonal Antibody (SPC-1313). Tissue: Breast Carcinoma Tissue. Species: Human. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-TGF beta 3 Polyclonal Antibody (SPC-1313) at 1:100. The image on the right is treated with the synthesized peptide.</p>

Immunohistochemistry analysis using Rabbit Anti-TGF beta 3 Polyclonal Antibody (SPC-1313). Tissue: Breast Carcinoma Tissue. Species: Human. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-TGF beta 3 Polyclonal Antibody (SPC-1313) at 1:100. The image on the right is treated with the synthesized peptide.

<p>Western blot analysis of Monkey Cos7 cell lysates showing detection of ~12.5kDa TGF beta 3 protein using Rabbit Anti-TGF beta 3 Polyclonal Antibody (SPC-1313). Lane 1: Monkey Cos7 cells. Lane 2: Monkey Cos7 treated with the immunizing peptide. Primary Antibody: Rabbit Anti-TGF beta 3 Polyclonal Antibody (SPC-1313) at 1:1000. Predicted/Observed Size: ~12.5kDa .</p>

Western blot analysis of Monkey Cos7 cell lysates showing detection of ~12.5kDa TGF beta 3 protein using Rabbit Anti-TGF beta 3 Polyclonal Antibody (SPC-1313). Lane 1: Monkey Cos7 cells. Lane 2: Monkey Cos7 treated with the immunizing peptide. Primary Antibody: Rabbit Anti-TGF beta 3 Polyclonal Antibody (SPC-1313) at 1:1000. Predicted/Observed Size: ~12.5kDa .

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HRP (Horseradish peroxidase)

Properties:

  • Enzymatic activity is used to amplify weak signals and increase visibility of a target
  • Readily combines with hydrogen peroxide (H2O2) to form HRP-H2O2 complex which can oxidize various hydrogen donors
  • Catalyzes the conversion of:
    • Chromogenic substrates (e.g. TMB, DAB, ABTS) into coloured products
    • Chemiluminescent substrates (e.g. luminol and isoluminol) into light emitting products via enhanced chemiluminescence (ECL)
    • Fluorogenic substrates (e.g. tyramine, homovanillic acid, and 4-hydroxyphenyl acetic acid) into fluorescent products
  • High turnover rate enables rapid generation of a strong signal
  • 44 kDa glycoprotein
  • Extinction coefficient: 100 (403 nm)
  • Applications: Western blot, immunohistochemistry, and ELISA

HRP Datasheet

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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