STRESTMARQ/柠檬酸他莫昔芬/SIH-389-100MG/100MG
商品编号：
SIH-389-100MG
市场价：
¥1100.00
美元价：
660.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | TamoxifenCitrate |
| Description | Autophagyinducer |
| Purity | >99% |
| CASNo. | 54965-24-1 |
| MolecularFormula | C26H29NO•C6H8O7 |
| MolecularWeight | 563.65 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inducer |
| Solubility | Solubleinmethanol(50mg/ml)orethanol;veryslightlysolubleinwateroracetone. |
| Source | Synthetic |
| Appearance | Whitetooff-whitepowder |
| SMILES | C(C(O)(C(=O)O)CC(=O)O)C(=O)O.C3=C(C(=C(C1=CC=CC=C1)CC)C2=CC=CC=C2)C=CC(=C3)OCCN(C)C |
| InChI | InChI=1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b |
| InChIKey | FQZYTYWMLGAPFJ-OQKDUQJOSA-N |
| SafetyPhrases | Classification:D2A-VeryToxicMaterialCausingOtherToxicEffects,Teratogen,Carcinogen,ReproductivehazardSafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H302-Harmfulifswallowed.H350-Maycausecancer.H360-Maydamagefertilityortheunbornchild.Precautionarystatements:P201-Obtainspecialinstructionsbeforeuse.P308+P313-IFexposedorconcerned:Getmedicaladvice/attention. |
| CiteThisProduct | TamoxifenCitrate(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-389) |
BIOLOGicalDescription
| AlternativeNames | (2)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanaminecitrate |
| ResearchAreas | Cancer,Autophagy |
| PubChemID | 2733525 |
| ScientificBackground | Tamoxifencitrateisanendocrinetherapydrugusedtotreatbreastcancer.Itactstointerruptestrogensignalingbyblockingtheestrogenreceptor(ER).Invivo,tamoxifenandtamoxafinmetabolitesbindtoestrogenreceptors,causingthetranscriptionofestrogen-responsegenestobeinhibited.Invitro,TamoxifenisknowntoinhibitproteinkinaseCthroughestrogenreceptor-independentantineoplasticeffects.Thisdrugthereforehasimportantapplicationsinbreastcancerresearch,particularlyinER+breastcancers.Recentstudieshaveshowntamoxifen-resistantcellsuseautophagyasasurvivalmechanism. |
| References | 1.Thomas,S.etal.(2011).BreastCancerResTreat,130(2):437-47. 2.Ma,J.etal.(2014).BMCCancer,14:172. 3.Patel,S.etal.(2012).IntJRADIatOncolBiolPhys,82(2):739-42. 4.Wang,D.etal.(2004).MolEndocrinol.402-11. |
ProductImages
ChemicalstructureofTamoxifenCitrate(SIH-389),aAutophagyinducer.CAS#:54965-24-1.MolecularFormula:C26H29NO.C6H8O7.MolecularWeight:563.65g/mol.
ProductCitations(0)
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
