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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-TAK1 Antibody (pSer439)/SPC-1086D-A594/100-µl
商品详细StressMarq/Anti-TAK1 Antibody (pSer439)/SPC-1086D-A594/100-µl
StressMarq/Anti-TAK1 Antibody (pSer439)/SPC-1086D-A594/100-µl
StressMarq/Anti-TAK1 Antibody (pSer439)/SPC-1086D-A594/100-µl
商品编号: SPC-1086D-A594
市场价: ¥6840.00
美元价: 4104.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

Product Name TAK1 Antibody (pSer439)
Description

Rabbit Anti-Human TAK1 (pSer439) Polyclonal

Species Reactivity Human
Applications WB, AM
Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen A phospho-specific peptide corresponding to residues surrounding Ser439 of human TAK1 (AA436-442)
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Peptide Affinity Purified
Clonality Polyclonal
Specificity Detects 67.196 kDa.
Cite This Product StressMarq Biosciences Cat# SPC-1086, RRID: AB_2709947
Certificate of Analysis A 1:250 dilution of SPC-1086 was sufficient for detection of TAK1 (pSer439) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names M3K7_HUMAN Antibody, MAP3K 7 Antibody, Map3k7 Antibody, MEKK7 Antibody, Mitogen activated protein kinase kinase kinase 7 Antibody, Mitogen-activated protein kinase kinase kinase 7 Antibody, TAK1 Antibody, TGF beta activated kinase 1 Antibody, TGF-beta-activated kinase 1 Antibody, TGF1a Antibody, Transforming growth factor beta activated kinase 1 Antibody, Transforming growth factor-beta-activated kinase 1 Antibody
Cellular Localization Cytoplasm, Cell membrane
Accession Number NP_663304
Gene ID 6885
Swiss Prot O43318
Scientific Background TAK1 encoded by the gene MAP3K7, is a protein-serine/threonine kinase that is activated by proinflammatory cytokines and in response to physical/chemical stress, including UVR, osmotic- and oxidative stress. It is a mediator of TRAF6 and TGF-β signal transduction, and activates IKBKB and MAPK8 in response to TRAF6 signalling. It also stimulates NFκB activation and activation of the p38 MAPK pathway. It is responsible for controlling a variety of cell functions such as transcription and apoptosis. TAK1 is important for TGF-β1 regulation of MMP9 and the metastatic potential of certain breast cancer cell lines.

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 ATTO 594
Overview:

  • High fluorescence yield
  • High photostability
  • Very hydrophilic
  • Excellent solubility in water
  • Very little aggregation
  • New dye with net charge of -1
  • Molar Mass: 1137 g/mol

ATTO 594 Datasheet

 ATTO 594 Fluorophore Excitation and Emission SpectrumOptical Properties:

λex = 601 nm

λem = 627 nm

εmax = 1.2×105

Φf = 0.85

τfl = 3.5 ns

Brightness = 102

Laser = 594 nm

Filter set = Texas Red®

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。