应力MARQ/1-磷酸鞘氨醇，D-红/SIH-386-1MG/1-mg
商品编号：
SIH-386-1MG
市场价：
¥2980.00
美元价：
1788.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Sphingosine-1-phosphate,D-erythro |
| Description | Signalingmolecule |
| Purity | >98% |
| CASNo. | 26993-30-6 |
| MolecularFormula | C18H38NO5P |
| MolecularWeight | 379.5 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | SecondMessenger |
| Solubility | Sparinglysolublein1:1ethanol:water.Additionofsmallamountsofaceticacidmayhelpdissolvethisproduct.Solubleinwarmmethanol. |
| Source | Synthetic |
| Appearance | Whitesolid |
| SMILES | [[email protected]@H](N)([[email protected]](O)C=CCCCCCCCCCCCCC)CO[P](=O)(O)O |
| InChI | InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1 |
| InChIKey | DUYSYHSSBDVJSM-KRWOKUGFSA-N |
| SafetyPhrases | Classification:Caution.Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionS24/25-AvoidcontactwithskinandeyesHazardPhrases:H315-Causesskinirritation.H319-Causesseriouseyeirritation.H335-Maycauserespiratoryirritation.PrecautionaryPhrases:P261Avoidbreathingdust/fume/gas/mist/vapours/spray.P280Wearprotectivegloves/protectiveclothing/eyeprotection/faceprotection.P305+P351+P338IFINEYES:Rinsecautiouslywithwaterforseveralminutes.Removecontactlenses,ifpresentandeasytodo.ContinuerinsingP321Specifictreatment(seeonthislabel).P405Storelockedup.P501Disposeofcontents/containerinaccordancewithlocal/regional/national/internationalregulations |
| CiteThisProduct | Sphingosine-1-phosphate,D-erythro(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-386) |
BIOLOGicalDescription
| AlternativeNames | [(E,2S,3R)-2-Amino-3-hydroxyoctadec-4-enyl]dihydrogenphosphate |
| ResearchAreas | CellSignaling |
| PubChemID | 5283560 |
| ScientificBackground | D-erythro-Sphingosine-1-phosphate(S1P)isapolarsphingolipidmetabolitewhichregulatesdiversecellularresponsesincludingcellgrowth,survivalandmigration.S1PwasreportedtostimulateDNAsynthesisandcelldivisioninquiescentculturesofSwiss3T3fibroblastsandtotriggerthedualsignaltransductionpathwaysofcalciummobilizationandPC-PLD(phospholipaseD)activation.S1PservesasasecondmessengerforintracellularcalciummobilizationinU-937cells(sc-2239)anddecreasescellularcAMP.RecentstudiesshowthatS1PisaG-protein-coupledreceptor(GPCR)ligandfortheEDG-1family,includingEDG-1,-3,-5,-6and-8.ThisbioactivelipidmediatorhasbeenshowntostimulatetheERKpathwayandtoalsocounteracttheceramide-inducedactivationofstress-activatedproteinkinase(SAPK/JNK).ResearchershavealsofoundthatS1PisastronginhibitorofcellmotilityandphagokinesisinB16melanomacells.Additionally,itinducesrapidandtransienttyrosinephosphorylationofepidermalgrowthfactorreceptor(EGFR)andc-Metingastriccancercells.S1Phasalsobeenknownasatumor-promotinglipid.SuggestedtobeanactivatorofGPR3,GPR6,andGPR12.D-erythro-Sphingosine-1-phosphateisanactivatorofEDG-1,EDG-3,EDG-2,EDG-4andEDG-5.¬ |
| References | 1.VanVeldhovenP.P.,etal.(1989).J.LipidRes.30(4):611-6. 2.DesaiN.N.,etal.(1992).J.Biol.Chem.267(32):23122-8. 3.SadahiraY.,etal.(1992).Proc.Natl.Acad.Sci.U.S.A.89(20):9686-90. 4.OliveraA.andSpiegel,S.(1993).Nature.365(6446):557-60. 5.MattieM.,etal.(1994).J.Biol.Chem.269(5):3181-8. 6.WuJ.,etal.(1995).J.Biol.Chem.270(19):11484-8. 7.ChoiO.H.,etal.(1996).Nature.380(6575):634-6. 8.CuvillierO.,etal.(1996).Nature.381(6585):800-3. 9.SpiegelS.,etal.(2000).Biochim.Biophys.Acta.1484(2-3):107-16. 10.SpiegelS.andMilstien,S.(2000).FEBSLett.476(1-2):55-57. 11.Shida,D.,etal.(2004).FEBSLett.577(3):333-8. 12.Watterson,K.R.,etal.(2005).Cell.Signal.17(3):289-98. |
ProductImages
ChemicalstructureofSphingosine-1-phosphate,D-erythro(SIH-386),aEndogenoussignalingmolecule.CAS#:26993-30-6.MolecularFormula:C18H38NO5P.MolecularWeight:379.5g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
