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当前位置： 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-SOD (Cu/Zn) Antibody/SPC-116D-BI/100-µg
商品详细StressMarq/Anti-SOD (Cu/Zn) Antibody/SPC-116D-BI/100-µg
StressMarq/Anti-SOD (Cu/Zn) Antibody/SPC-116D-BI/100-µg
StressMarq/Anti-SOD (Cu/Zn) Antibody/SPC-116D-BI/100-µg
商品编号： SPC-116D-BI
市场价： ¥7020.00
美元价： 4212.00
产地： 美国(厂家直采)
公司：
产品分类： 酸碱缓冲液
公司分类： acid_base_buffer_solution
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

ProductNameSOD(Cu/Zn)Antibody
Description

RabbitAnti-HumanSOD(Cu/Zn)Polyclonal

SpeciesReactivityDog,Human,Monkey,Mouse,Rat,Africanclawedfrog(Xenopuslaevis),Bovine,Butterfly(Opsmelastigma),Coral(Anthozoa),Fish,Hamster,Insect,Invertebrate,Mollusk,Mussel(Pernaviridis),Pig,Rabbit,Sheep
ApplicationsWB,IHC,IP,ELISA
AntibodyDilutionWB(1:5000),IHC(1:100);optimaldilutionsforassaysshouldbedeterminedbytheuser.
HostSpeciesRabbit
ImmunogenSpeciesHuman
ImmunogenHumanCu/ZnSOD
Concentration1mg/ml
ConjugatesAlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBufferPBSpH7.0,50%glycerol,0.09%sodiumazide
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationProteinApurified
ClonalityPolyclonal
SpecificityDetects~23kDa(human)and~19kDa(otherspecies).
CiteThisProductStressMarqBiosciencesCat#SPC-116,RRID:AB_2239732
CertificateofAnalysis0.2µg/mlofSPC-116wassufficientfordetectionofCu/ZnSODin20µgofHeLacelllysatebycolorimetricimmunoblotanalysisusingGoatanti-rabbitIgG:APasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNamesSuperoxidedismutase1Antibody,ALS1Antibody,IPOAAntibody,SOD1Antibody,SOD2Antibody,SODCAntibody
ResearchAreasCancer,ALSDisease,CellSignaling,ChaperoneProteins,Neurodegeneration,Neuroscience,OxidativeStress,ProteinTrafficking
CellularLocalizationCytoplasm
AccessionNumberNP_000445.1
GeneID6647
SwissProtP00441
ScientificBackgroundSuperoxidedismutase(SOD)isanendogenouslyproducedintracellularenzymepresentinalmosteverycellinthebody(3).ItworksbycatalyzingthedismutationofthesuperoxiderADIcalO2ˉtoO2andH2O2,whicharethenmetabolizedtoH2OandO2bycatalaseandglutathioneperoxidase(2,5).Ingeneral,SODsplayamajorroleinantioxidantdefensemechanisms(4).TherearetwomaintypesofSODinmammaliancells.Oneform(SOD1)containsCuandZnionsasahomodimerandexistsinthecytoplasm.Thetwosubunitsof16kDaeacharelinkedbytwocysteinesforminganintra-subunitdisulphidebridge(3).Thesecondform(SOD2)isamanganesecontainingenzymeandresidesinthemitochondrialmatrix.Itisahomotetramerof80kDa.Thethirdform(SOD3orEC-SOD)islikeSOD1inthatitcontainsCuandZnions,howeveritisdistinctinthatitisahomotetramer,withamassof30kDAanditexistsonlyintheextra-cellularspace(7).SOD3canalsobedistinguishedbyitsheparin-bindingcapacity(1).
References1.AdachiT.,etal.(1992).Clin.Chim.Acta.212:89-102.
2.BarristerJ.V.,etal.(1987).Crit.Rev.Biochem.22:111-180.
3.FurukawaY.,O’HalloranT.(2006).Antioxidants&RedoSignaling.Vol8,No5,6.
4.GaoB.,etal.(2003).AmJPhysiolLungCellMolPhysiol284:L917-L925.
5.HassanH.M.(1988).FreeRadicalBiol.Med.5:377-385.
6.KurobeN.,etal.(1990)BiomedicalResearch.11:187-194
7.WispeJ.R.,etal.(1989)BBA.994:30-36.
8.Xiao-HongLiu.,etal.(1993)BrainResearch.625:29-37.

ProductImages

<p>Immunohistochemistry analysis using Rabbit Anti-SOD1 Polyclonal Antibody (SPC-116). Tissue: Placenta. Species: Human. Primary Antibody: Rabbit Anti-SOD1 Polyclonal Antibody (SPC-116) at 1:100. Courtesy of: Courtesy of Joan Telfer, University of Glasgow.</p>

ImmunohistochemistryanalysisusingRabbitAnti-SOD1PolyclonalAntibody(SPC-116).Tissue:Placenta.Species:Human.PrimaryAntibody:RabbitAnti-SOD1PolyclonalAntibody(SPC-116)at1:100.Courtesyof:CourtesyofJoanTelfer,UniversityofGlasgow.

<p>Western blot analysis of Human Cell line lysates showing detection of SOD1 protein using Rabbit Anti-SOD1 Polyclonal Antibody (SPC-116). Load: 15 µg protein. Block: 1.5% BSA. Primary Antibody: Rabbit Anti-SOD1 Polyclonal Antibody (SPC-116) at 1:1000 for 2 hours at RT. Secondary Antibody: Donkey Anti-Rabbit IgG: HRP for 1 hour at RT.</p>

WesternblotanalysisofHumanCelllinelysatesshowingdetectionofSOD1proteinusingRabbitAnti-SOD1PolyclonalAntibody(SPC-116).Load:15µgprotein.Block:1.5%BSA.PrimaryAntibody:RabbitAnti-SOD1PolyclonalAntibody(SPC-116)at1:1000for2hoursatRT.SecondaryAntibody:DonkeyAnti-RabbitIgG:HRPfor1houratRT.

ProductCitations(5)

WesternBlot

Differentialproteomicresponsesinhepatopancreasandadductormusclesofthegreen-lippedmusselPernaviridistostressesinducedbycadmiumandhydrogenperoxide.

Leung,P.T.Y.,Wang,Y.,Mak,S.S.T.andLeung,K.M.Y.(2011)AquatToxicol.105(1-2):49-61.

PubMedID:21684241ReactivityPernaviridis(Asiangreenmussel)Applications:WesternBlot

Ischemicconditioningbyshortperiodsofreperfusionattenuatesrenalischemia/reperfusioninducedapoptosisandautophagyintherat.

Wu,H.,Hsiao,T.,Chien,C.,andLai,M.(2009)JBiomedSci.16(19).

PubMedID:19272187ReactivityRatApplications:WesternBlot

Sesaminmodulatestyrosinehydroxylase,superoxidedismutase,catalase,inducIBLeNOsynthaseandinterleukin-6expressionindopaminergiccellsunderMPP+-inducedoxidativestress.

Lahaie-Collins,V.,Bournival,J.,Plouffe,M.,Carange,J.andMatinoli,M.G.(2008)OxidMedCellLongev.1(1):54-62.

PubMedID:19794909ReactivityRatApplications:WesternBlot

OtherCitations

Toxicitiesofnanozincoxidetofivemarineorganisms:influencesofaggregatesizeandionsolubility.

Wong,S.W.,Leung,P.T.,Djurisic,A.B.andLeung,K.M.(2010)AnalBioanalChem.396(2):609-618.

PubMedID:19902187ReactivityFish(O.melastigma)Applications:WesternBlot

SialicAcidReducesAcuteEndotoxemia-InducedLiverDysfunctionintheRat.

Ho,C.,Hsu,S.,Yang,C.,Lee,Y.andChien,C.(2009)Shock.32(2):228-235.

PubMedID:19060786ReactivityRatApplications:WesternBlot

BiotinBiotin Conjugate Structure

Properties:

  • BindstetramericavidinproteinsincludingStreptavidinandneuravidinwithveryhighaffinity
  • Molarmass:244.31g/mol
  • Formula:C10H16N2O3S
  • Applications:Westernblot,immunohistochemistry,andELISA

BiotinDatasheet

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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