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当前位置： 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-SOD (Cu/Zn) Antibody/SPC-116D-A633/100-µg
商品详细StressMarq/Anti-SOD (Cu/Zn) Antibody/SPC-116D-A633/100-µg
StressMarq/Anti-SOD (Cu/Zn) Antibody/SPC-116D-A633/100-µg
StressMarq/Anti-SOD (Cu/Zn) Antibody/SPC-116D-A633/100-µg
商品编号： SPC-116D-A633
市场价： ¥7100.00
美元价： 4260.00
产地： 美国(厂家直采)
公司：
产品分类： 酸碱缓冲液
公司分类： acid_base_buffer_solution
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

Product Name SOD (Cu/Zn) Antibody
Description

Rabbit Anti-Human SOD (Cu/Zn) Polyclonal

Species Reactivity Dog, Human, Monkey, Mouse, Rat, African clawed frog (Xenopus laevis), Bovine, Butterfly (Ops melastigma), Coral (Anthozoa), Fish, Hamster, Insect, Invertebrate, Mollusk, Mussel (Perna viridis), Pig, Rabbit, Sheep
Applications WB, IHC, IP, ELISA
Antibody Dilution WB (1:5000), IHC (1:100); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen Human Cu/Zn SOD
Concentration 1 mg/ml
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH7.0, 50% glycerol, 0.09% sodium azide
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Protein A purified
Clonality Polyclonal
Specificity Detects ~23kDa (human) and ~19kDa (other species).
Cite This Product StressMarq Biosciences Cat# SPC-116, RRID: AB_2239732
Certificate of Analysis 0.2 µg/ml of SPC-116 was sufficient for detection of Cu/Zn SOD in 20 µg of HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:AP as the secondary antibody.

Biological Description

Alternative Names Superoxide dismutase1 Antibody, ALS1 Antibody, IPOA Antibody, SOD1 Antibody, SOD2 Antibody, SODC Antibody
Research Areas Cancer, ALS Disease, Cell Signaling, Chaperone Proteins, Neurodegeneration, Neuroscience, Oxidative Stress, Protein Trafficking
Cellular Localization Cytoplasm
Accession Number NP_000445.1
Gene ID 6647
Swiss Prot P00441
Scientific Background Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2ˉ to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2,5). In general, SODs play a major role in antioxidant defense mechanisms (4). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space (7). SOD3 can also be distinguished by its heparin-binding capacity (1).
References 1. Adachi T., et al. (1992). Clin. Chim. Acta. 212: 89-102.
2. Barrister J.V., et al. (1987). Crit. Rev. Biochem. 22:111-180.
3. Furukawa Y., O’Halloran T. (2006). Antioxidants & Redo Signaling. Vol 8, No 5,6.
4. Gao B., et al. (2003). Am J Physiol Lung Cell Mol Physiol 284: L917-L925.
5. Hassan H.M. (1988). Free Radical Biol. Med. 5: 377-385.
6. Kurobe N., et al. (1990) Biomedical Research. 11: 187-194
7. Wispe J.R., et al. (1989) BBA. 994: 30-36.
8. Xiao-Hong Liu., et al. (1993) Brain Research. 625: 29-37.

Product Images

<p>Immunohistochemistry analysis using Rabbit Anti-SOD1 Polyclonal Antibody (SPC-116). Tissue: Placenta. Species: Human. Primary Antibody: Rabbit Anti-SOD1 Polyclonal Antibody (SPC-116) at 1:100. Courtesy of: Courtesy of Joan Telfer, University of Glasgow.</p>

Immunohistochemistry analysis using Rabbit Anti-SOD1 Polyclonal Antibody (SPC-116). Tissue: Placenta. Species: Human. Primary Antibody: Rabbit Anti-SOD1 Polyclonal Antibody (SPC-116) at 1:100. Courtesy of: Courtesy of Joan Telfer, University of Glasgow.

<p>Western blot analysis of Human Cell line lysates showing detection of SOD1 protein using Rabbit Anti-SOD1 Polyclonal Antibody (SPC-116). Load: 15 µg protein. Block: 1.5% BSA. Primary Antibody: Rabbit Anti-SOD1 Polyclonal Antibody (SPC-116) at 1:1000 for 2 hours at RT. Secondary Antibody: Donkey Anti-Rabbit IgG: HRP for 1 hour at RT.</p>

Western blot analysis of Human Cell line lysates showing detection of SOD1 protein using Rabbit Anti-SOD1 Polyclonal Antibody (SPC-116). Load: 15 µg protein. Block: 1.5% BSA. Primary Antibody: Rabbit Anti-SOD1 Polyclonal Antibody (SPC-116) at 1:1000 for 2 hours at RT. Secondary Antibody: Donkey Anti-Rabbit IgG: HRP for 1 hour at RT.

Product Citations (5)

Western Blot

Differential proteomic responses in hepatopancreas and adductor muscles of the green-lipped mussel Perna viridis to stresses induced by cadmium and hydrogen peroxide.

Leung, P.T.Y., Wang, Y., Mak, S.S.T. and Leung, K. M.Y. (2011) Aquat Toxicol. 105 (1-2): 49-61.

PubMed ID: 21684241 Reactivity Perna viridis (Asian green mussel) Applications: Western Blot

Ischemic conditioning by short periods of reperfusion attenuates renal ischemia/reperfusion induced apoptosis and autophagy in the rat.

Wu, H., Hsiao, T., Chien, C., and Lai, M. (2009) J Biomed Sci. 16 (19).

PubMed ID: 19272187 Reactivity Rat Applications: Western Blot

Sesamin modulates tyrosine hydroxylase, superoxide dismutase, catalase, inducible NO synthase and interleukin-6 expression in dopaminergic cells under MPP+-induced oxidative stress.

Lahaie-Collins, V., Bournival, J., Plouffe, M., Carange, J. and Matinoli, M.G. (2008) Oxid Med Cell Longev. 1 (1): 54-62.

PubMed ID: 19794909 Reactivity Rat Applications: Western Blot

Other Citations

Toxicities of nano zinc oxide to five marine organisms: influences of aggregate size and ion solubility.

Wong, S.W., Leung, P.T., Djurisic, A.B. and Leung, K.M. (2010) Anal Bioanal Chem. 396 (2): 609-618.

PubMed ID: 19902187 Reactivity Fish (O. melastigma) Applications: Western Blot

Sialic Acid Reduces Acute Endotoxemia-Induced Liver Dysfunction in the Rat.

Ho, C., Hsu, S., Yang, C., Lee, Y. and Chien, C. (2009) Shock. 32 (2): 228-235.

PubMed ID: 19060786 Reactivity Rat Applications: Western Blot

 ATTO 633
Overview:

  • High fluorescence yield
  • High thermal and photostability
  • Moderately hydrophilic
  • Good solubility in polar solvents
  • Stable at pH 4 – 11
  • Cationic dye, perchlorate salt
  • Molar Mass: 652.2 g/mol

ATTO 633 Datasheet

ATTO 633 Fluorophore Absorption and Emission SpectrumOptical Properties:

λex = 629 nm

λem = 657 nm

εmax = 1.3×105

Φf = 0.64

τfl = 3.2 ns

Brightness = 83.2

Laser = 633 nm

Filter set = Cy®5

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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