StressMarq/SB203580/SIH-474-5MG/5-mg
商品编号：
SIH-474-5MG
市场价：
¥3500.00
美元价：
2100.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | SB203580 |
| Description | p38MAPkinaseinhibitor |
| Purity | >98%(HPLC) |
| CASNo. | 152121-47-6 |
| MolecularFormula | C21H16FN3OS |
| MolecularWeight | 377.4 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO(50mg/ml) |
| Source | Synthetic |
| Appearance | Whitetooff-whitepowder |
| SMILES | C1=C(C=CC(=C1)C2=C([NH]C(=N2)C3=CC=C(C=C3)[S](C)=O)C4=CC=NC=C4)F |
| InChI | InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) |
| InChIKey | CDMGBJANTYXAIV-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Acutetoxicity,Oral(Category4),H302Seriouseyedamage(Category1),H318SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H302Harmfulifswallowed.H318Causesseriouseyedamage.Precautionarystatements:P264Washskinthoroughlyafterhandling.P270Donoteat,drinkorsmokewhenusingthisproduct.P280Wearprotectivegloves/eyeprotection/faceprotection.P301+P312IFSWALLOWED:CallaPOISONCENTERordoctor/physicianifyoufeelunwell.P305+P351+P338IFINEYES:Rinsecautiouslywithwaterforseveralminutes.Removecontactlenses,ifpresentandeasytodo.Continuerinsing.P310ImmediatelycallaPOISONCENTERordoctor/physician.P330Rinsemouth.P501Disposeofcontents/containertoanapprovedwastedisposalplant |
| CiteThisProduct | SB203580(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-474) |
BIOLOGicalDescription
| AlternativeNames | 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole |
| ResearchAreas | Cancer,Apoptosis,CancerGrowthInhibitors,CellSignaling,TyrosineKinaseInhibitors |
| PubChemID | 176155 |
| ScientificBackground | SB203580isaapyridinylimidazolethatinhibitsp38MAPkinase.SB203580hasalsobeenshowntoinhibitheatshockprotein27(HSP27)phosphorylationandhasbeenshowntoinducetheactivationofRaf-1.Itdisplays100-500-foldselectivityoverLCK,GSK-3βandPKBα.SB203580iscellpermeable. |
| References | 1.Hall-JacksonC.A.,GoedertM.,HedgeP.,&CohenP.(1999)Oncogene.18(12):2047–2054. 2.Saklatvala,J.,etal.(1996)J.Bio.Chem.271(12):6586–6589. 3.CuendaA.,etal.(1995)FEBSLetters.364(2):229–233. |
ProductImages
ChemicalstructureofSB203580(SIH-474),ap38MAPkinaseinhibitor.CAS#:152121-47-6.MolecularFormula:C21H16FN3OS.MolecularWeight:377.4g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
