StressMarq/SB202190/SIH-473-5MG/5-mg
商品编号：
SIH-473-5MG
市场价：
¥1700.00
美元价：
1020.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | SB202190 |
| Description | p38MAPkinaseinhibitor |
| Purity | >98%(TLC) |
| CASNo. | 152121-30-7 |
| MolecularFormula | C20H14FN3O |
| MolecularWeight | 331.3 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | Solubleinmethanol,DMSOoracetone;slightlysolubleinethylacetate |
| Source | Synthetic |
| Appearance | Paleyellowsolid |
| SMILES | C4=C(C1=C(NC(N1)=C2C=CC(=O)C=C2)C3=CC=NC=C3)C=CC(=C4)F |
| InChI | InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,23-24H |
| InChIKey | NJNKPVPFGLGHPA-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Skinirritation(Category2),H315Eyeirritation(Category2A),H319Specifictargetorgantoxicity-singleexposure(Category3),Respiratorysystem,H335SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H315Causesskinirritation.H319Causesseriouseyeirritation.H335Maycauserespiratoryirritation.Precautionarystatements:P261Avoidbreathingdust/fume/gas/mist/vapours/spray.P264Washskinthoroughlyafterhandling.P271Useonlyoutdoorsorinawell-ventilatedarea.P280Wearprotectivegloves/eyeprotection/faceprotection.P302+P352IFONSKIN:Washwithplentyofsoapandwater.P304+P340IFINHALED:Removevictimtofreshairandkeepatrestinapositioncomfortableforbreathing.P305+P351+P338IFINEYES:Rinsecautiouslywithwaterforseveralminutes.Removecontactlenses,ifpresentandeasytodo.Continuerinsing.P312CallaPOISONCENTERordoctor/physicianifyoufeelunwell.P321Specifictreatment(seesupplementalfirstaidinstructionsonthislabel).P332+P313Ifskinirritationoccurs:Getmedicaladvice/attention.P337+P313Ifeyeirritationpersists:Getmedicaladvice/attention.P362Takeoffcontaminatedclothingandwashbeforereuse.P403+P233Storeinawell-ventilatedplace.Keepcontainertightlyclosed.P405Storelockedup.P501Disposeofcontents/containertoanapprovedwastedisposalplant |
| CiteThisProduct | SB202190(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-473) |
BIOLOGicalDescription
| AlternativeNames | FHPI,4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole |
| ResearchAreas | Cancer,Apoptosis,CancerGrowthInhibitors,CellSignaling,TyrosineKinaseInhibitors |
| PubChemID | 5353940 |
| ScientificBackground | SB202190isahighlyselectiveandpotentinhibitorofp38MAPkinase.Specifically,itbindswithintheATPpocketoftheactivekinaseandselectivelyinhibitsthep38αandβisoforms.Ithasbeenshowntoinduceapoptosis.SB202190iscell-permeable. |
| References | 1.NemotoS.,XiangJ.,HuangS.,&LinA.(1998)J.Bio.Chem.273(26):16415–16420. 2.KarahashiH.,NagataK.,IshiiK.,&AmanoF.(2000)BiochimicaEtBiophysicaActa.1502(2):207–223. |
ProductImages
ChemicalstructureofSB202190(SIH-473),ap38MAPkinaseinhibitor.CAS#:152121-30-7.MolecularFormula:C20H14FN3O.MolecularWeight:331.3g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
