StressMarq/Rolipram/SIH-401-10MG/10-mg
商品编号：
SIH-401-10MG
市场价：
¥1500.00
美元价：
900.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Rolipram |
| Description | Autophagyinhibitor |
| Purity | >98%(TLC);NMR(Conforms) |
| CASNo. | 61413-54-5 |
| MolecularFormula | C16H21NO3 |
| MolecularWeight | 275.35 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | Solubleto75mMinDMSOandto75mMinethanol. |
| Source | Synthetic |
| Appearance | Whitetooff-whitesolid. |
| SMILES | C1=C(C(=CC=C1C2CNC(C2)=O)OC)OC3CCCC3 |
| InChI | InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) |
| InChIKey | HJORMJIFDVBMOB-UHFFFAOYSA-N |
| SafetyPhrases | Classification:D2B-ToxicMaterialCausingOtherToxicEffects,Moderateskinirritant,Moderaterespiratoryirritant,ModerateeyeirritantSafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H315-Causesskinirritation.H319-Causesseriouseyeirritation.H335-Maycauserespiratoryirritation.Precautionarystatements:P261-Avoidbreathingdust/fume/gas/mist/vapours/spray.P264-Washskinthoroughlyafterhandling.P271-Useonlyoutdoorsorinawell-ventilatedarea.P280-Wearprotectivegloves/eyeprotection/faceprotection.P302+P352-IFONSKIN:Washwithplentyofsoapandwater.P304+P340-IFINHALED:Removevictimtofreshairandkeepatrestinapositioncomfortableforbreathing.P305+P351+P338-IFINEYES:Rinsecautiouslywithwaterforseveralminutes.Removecontactlenses,ifpresentandeasytodo.Continuerinsing.P312-CallaPOISONCENTERordoctor/physicianifyoufeelunwell.P321-Specifictreatment(seesupplementalfirstaidinstructionsonthislabel).P332+P313-Ifskinirritationoccurs:Getmedicaladvice/attention.P337+P313-Ifeyeirritationpersists:Getmedicaladvice/attention.P362-Takeoffcontaminatedclothingandwashbeforereuse.P403+P233-Storeinawell-ventilatedplace.Keepcontainertightlyclosed.P405-Storelockedup.P501-Disposeofcontents/containertoanapprovedwastedisposalplant. |
| CiteThisProduct | Rolipram(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-401) |
BIOLOGicalDescription
| AlternativeNames | 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one |
| ResearchAreas | Cancer,Autophagy |
| PubChemID | 5092 |
| ScientificBackground | RolipramhasbeenobservedtoselectivelyinhibitcAMP-phosphodiesterase(PDE4)byrecruitingPDE4intocytosolicaggregatesthatarenotmembrane-encapsulated.Adown-streameffectofthisobservationistheinhibitionofautophagy.Undernormalconditions,autophagosomesarecoatedwiththeautophagicMarkerlightchain3(LC3).LC3bindsdirectlytop62protein,whichshuttlesproteintoaggresomes,eventuallyleADIngtoanautophagicevent.IntheabsenceofLC3,proteinaggregateswillnotundergoautophagy,andwillremainascytosolicaggregates,asseenwiththeinhibitionofPDE4byRolipram. |
| References | 1.KatoH.,etal.(1995)EurJPharmacol.272(1):107-10. 2.ChristianF.,etal.(2010)CellSignal.22(10):1576-96. 3.HouslayM.D.,&ChristianF.(2010)Autophagy.6(8):1198-200. |
ProductImages
ChemicalstructureofRolipram(SIH-401),aAutophagyinhibitor.CAS#:61413-54-5.MolecularFormula:C16H21NO3.MolecularWeight:275.35g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
