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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-RAGE Antibody/SPC-1292D-P594/100-µl
商品详细StressMarq/Anti-RAGE Antibody/SPC-1292D-P594/100-µl
StressMarq/Anti-RAGE Antibody/SPC-1292D-P594/100-µl
StressMarq/Anti-RAGE Antibody/SPC-1292D-P594/100-µl
商品编号: SPC-1292D-P594
市场价: ¥6180.00
美元价: 3708.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNameRAGEAntibody
Description

RabbitAnti-HumanRAGEPolyclonal

SpeciesReactivityHuman
ApplicationsWB,IHC,ICC/IF
AntibodyDilutionWB(1:1000),IHC(1:200);optimaldilutionsforassaysshouldbedeterminedbytheuser.
HostSpeciesRabbit
ImmunogenSpeciesHuman
ImmunogenAsynthesizedpeptidederivedfromhumanRAGE
ConjugatesAlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBufferPBSpH7.4,50%glycerol,150mMNaCl,0.02%sodiumazide
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationAffinityPurified
ClonalityPolyclonal
IsotypeIgG
SpecificityDetects~42kDa,endogenouslevelsoftotalRAGE.
CiteThisProductStressMarqBiosciencesCat#SPC-1292,RRID:AB_2713061
CertificateofAnalysisA1:1000dilutionofSPC-1292wassufficientfordetectionofRAGEin10µgofhumanbraincelllysatesbyECLimmunoblotanalysisusingGoatAnti-RabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNamesAdvancedglycosylationendproduct-specificreceptorAntibody,AgerAntibody,MGC2235Antibody,RAGE_HUMANAntibody,ReceptorforadvancedglycosylationendproductsAntibody
ResearchAreasAlzheimer"sDisease,Alzheimer’sDisease,Atherosclerosis,CardiovascularSystem,Neurodegeneration,Neuroscience
CellularLocalizationCellmembrane,Secreted
AccessionNumberNP_001127.1
GeneID177
SwissProtQ15109
ScientificBackgroundRAGE,thereceptorforadvancedglycationendproducts,isa35kDatransmembranereceptoroftheimmunoglobulinsuperfamilywhichwasfirstcharacterizedin1992byNeeperetal.Itisalsocalled"AGER".TheincreasedexpressionofRAGEisassociatedwithmanydisorders,suchasdiabeticvasculopathy,neuropathy,retinopathyandneuropathy,Alzheimer’sdiseaseandimmune/inflammatoryreactionsofthevesselwalls.ItisreportedthatRAGEalongwithAmphoterinstimulatesmyoblastdifferentiationbythecombinedeffectofstimulationofdifferentiationandinhibitionofproliferation,andderegulationofRAGEexpressioninmyoblastsmightcontributetotheirneoplastictransformation.
References1.NeeperM.etal.(1992)TheJournalofBiologicalChemistry267(21):14998–5004.
2.BierhausA.etal.(2001)Diabetes50(12):2792–808.
3.HudsonBI.etal.(2001)Diabetes50(6):1505–11.

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 PE/ATTO594
PE/ATTO594isatandemconjugate,wherePEisexcitedat535nmandtransfersenergytoATTO594viaFRET(fluorescenceresonanceenergytransfer),whichemitsat627nm.
Overview:
  • Highfluorescenceyield
  • HighphotostABIlity
  • Veryhydrophilic
  • Excellentsolubilityinwater
  • Verylittleaggregation

PE/ATTO594Datasheet

PE-ATTO 594 Fluorophore Conjugate Excitation and Emission SpectraOpticalProperties:

λex =535nm

λem =627 nm

Laser = 488to561nm

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。