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当前位置： 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-RAGE Antibody/SPC-1292D-A488/100-µl
商品详细StressMarq/Anti-RAGE Antibody/SPC-1292D-A488/100-µl
StressMarq/Anti-RAGE Antibody/SPC-1292D-A488/100-µl
StressMarq/Anti-RAGE Antibody/SPC-1292D-A488/100-µl
商品编号： SPC-1292D-A488
市场价： ¥6040.00
美元价： 3624.00
产地： 美国(厂家直采)
公司：
产品分类： 酸碱缓冲液
公司分类： acid_base_buffer_solution
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

Product Name RAGE Antibody
Description

Rabbit Anti-Human RAGE Polyclonal

Species Reactivity Human
Applications WB, IHC, ICC/IF
Antibody Dilution WB (1:1000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen A synthesized peptide derived from human RAGE
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Affinity Purified
Clonality Polyclonal
Isotype IgG
Specificity Detects ~42kDa, endogenous levels of total RAGE.
Cite This Product StressMarq Biosciences Cat# SPC-1292, RRID: AB_2713061
Certificate of Analysis A 1:1000 dilution of SPC-1292 was sufficient for detection of RAGE in 10 µg of human brain cell lysates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names Advanced glycosylation end product-specific receptor Antibody, Ager Antibody, MGC2235 Antibody, RAGE_HUMAN Antibody, Receptor for advanced glycosylation end products Antibody
Research Areas Alzheimer's Disease, Alzheimer’s Disease, Atherosclerosis, Cardiovascular System, Neurodegeneration, Neuroscience
Cellular Localization Cell membrane, Secreted
Accession Number NP_001127.1
Gene ID 177
Swiss Prot Q15109
Scientific Background RAGE, the receptor for advanced glycation endproducts, is a 35 kDa transmembrane receptor of the immunoglobulin super family which was first characterized in 1992 by Neeper et al. It is also called "AGER". The increased expression of RAGE is associated with many disorders, such as diabetic vasculopathy, neuropathy, retinopathy and neuropathy, Alzheimer’s disease and immune/inflammatory reactions of the vessel walls. It is reported that RAGE along with Amphoterin stimulates myoblast differentiation by the combined effect of stimulation of differentiation and inhibition of proliferation, and deregulation of RAGE expression in myoblasts might contribute to their neoplastic transformation.
References 1. Neeper M. et al. (1992) The Journal of Biological Chemistry 267 (21): 14998–5004.
2. Bierhaus A. et al. (2001) Diabetes 50 (12): 2792–808.
3. Hudson BI. et al. (2001) Diabetes 50 (6): 1505–11.

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  ATTO 488
Overview:

  • High fluorescence yield
  • High photostability
  • Very hydrophilic
  • Excellent solubility in water
  • Very little aggregation
  • New dye with net charge of -1
  • Molar Mass: 804 g/mol 

ATTO 488 Datasheet

  ATTO 488 Fluorophore Excitation and Emission SpectraOptical Properties:

λex = 501 nm

λem = 523 nm

εmax = 9.0×104

Φf = 0.80

τfl = 4.1 ns

Brightness = 72

Laser = 488 nm

Filter set = FITC

 

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StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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