StressMarq/Radicicol/SIH-117A/1-mg
商品编号：
SIH-117A
市场价：
¥2460.00
美元价：
1476.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | RADIcicol |
| Description | Hsp90inhibitor |
| Purity | 97%byTLC |
| CASNo. | 12772-57-5 |
| MolecularFormula | C18H17CIO6 |
| MolecularWeight | 364.8 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO |
| Source | Producedbyfermentation |
| Appearance | WhitetoYellowSolid |
| SMILES | COc1ccc2c(=O)c(coc2c1OC)c3cc(c(cc3I)OC)OC |
| InChI | InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1 |
| InChIKey | WYZWZEOGROVVHK-GTMNPGAYSA-N |
| SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection |
| CiteThisProduct | Radicicol(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-117) |
BIOLOGicalDescription
| ResearchAreas | Cancer,HeatShock |
| PubChemID | 6323491 |
| ScientificBackground | Radicicolinhibitssrc(IC50=0.27µM)andsrc-likekinases(1),leadingtohypophosphorylationofretinoblastomatumorsuppressorprotein(2).Itcausesmorphologicalreversionofras-transformedcells(3)andleadstoselectivedepletionofRafkinase(4).Italsodisplaysanti-angiogenicactivity(5),andbindstoandinhibitsHsp90molecularchaperone(6).ItbindsmorestronglytoHsp90thantoGRP94.ItalsobindstoyeastHSP90,E.coliHtpGandTRAP-1.LookingformoreinformationonHSP90?VisitournewHSP90ScientificResourceGuideathttp://www.HSP90.ca. |
| References | 1.KwonH.J.,etal.(1992)CancerRes.52:6929. 2.YenA.,etal.(1994)Exp.CellRes.214:163. 3.KwonH.J.,etal.(1995)J.Biochem.(Tokyo)118:221. 4.SogaS.,etal.(1998)J.Biol.Chem.273:822. 5.OikawaT.,etal.(1993)Eur.J.Pharmacol.241:221. 6.RoeS.M.etal.(1999)J.Med.Chem.42:260. |
ProductImages
ChemicalstructureofRadicicol(SIH-117),aHsp90inhibitor.CAS#:12772-57-5.MolecularFormula:C18H17CIO6.MolecularWeight:364.8g/mol.
ProductCitations(1)
OtherCitations
TLN-4601,anovelanticanceragent,inhibitsRassignalingpostRasprenylationandbeforeMEKactivation.
Boufaied,N.,Wioland,M.,Falardeau,P.andGourdeau,H.(2010)AnticancerDrugs.21(5),543-552.
PubMedID:20220516Applications:Competitivebindingassay
品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
