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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Rab5 Protein/SPR-121B/100-µg
商品详细StressMarq/Rab5 Protein/SPR-121B/100-µg
StressMarq/Rab5 Protein/SPR-121B/100-µg
StressMarq/Rab5 Protein/SPR-121B/100-µg
商品编号: SPR-121B
市场价: ¥15460.00
美元价: 9276.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNameRab5Protein
Description

HumanRecombinantRab5Protein

ApplicationsWB,SDS-PAGE
ConcentrationLot/batchspecific.Seeincludeddatasheet.
ConjugatesHistag

Properties

StorageBuffer20mMTris/HClpH7.5,0.45MNaCl,10%glycerol,0.5mMDTT
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationAffinityPurified
Specificity~26kDa
CiteThisProductHumanRecombinantRab5Protein(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SPR-121)
CertificateofAnalysisThisproducthasbeencertified>90%pureusingSDS-PAGEanalysis.

BIOLOGicalDescription

AlternativeNamesRab5AProtein,RASassociatedproteinRAB5AProtein,RasrelatedproteinRab5AProtein
ResearchAreasCancer,HeatShock
CellularLocalizationCellmembrane,EarlyEndosomeMembrane,Melanosome
AccessionNumberBC001267
GeneID5868
SwissProtP20339
ScientificBackgroundRab5isa24kDamemberoftheRabfamilyofsmallguanosinetriphosphatases(GTPases),Rassuperfamily.RabGTPasesarecentralregulatorsofmembranetraffickingintheeukaryoticcell.TheirregulatorycapacitydependsontheirABIlitytocyclebetweentheGDP-boundinactiveandGTP-boundactivestates.ThisconversionisregulatedbyGDP/GTPexchangefactors(GEPs),GDPdissociationinhibitors(GDIs)andGTPase-activatingproteins(GAPs)(1,2).ActivationofaRabproteiniscoupledtoitsassociationwithintracellularmembranes,allowingittorecruitdownstreameffectorproteinstothecytoplasmicsurfaceofasubcellularcompartment(3).Throughtheseproteins,RabGTPasesregulatevesicleformation,actin-andtubulin-dependentvesiclemovement,andmembranefusion(1).Rabproteinscontainconservedregionsinvolvedinguanine-nucleotidebinding,andhypervariableCOHO-terminaldomainswithacysteinemotifimplicatedinsubcellulartargeting.Post-translationalmodificationofthecysteinemotifwithoneortwogeranylgroupsisessentialforthemembraneassociationandcorrectintracellularlocalizationofRabproteins(3).EachRabshowsacharacteristicsubcellulardistribution(4).Inparticular,Rab5isubiquitouslyexpressedinhumantissues.Itlocalizesmainlytoearlyendosomes,butisalsopresentontheplasmamembrane.Itregulatesthefusionbetweenendocyticvesiclesandearlyendosomes,aswellasthehomotypicfusionbetweenearlyendosomes(5).AmongtheproteinsrecruitedbytheGTP-boundactiveRab5areRabaptin-5andEEA1(6).Anti-Rab5maybeusedasanearlyendosomeMarker.
References1.StenmarkH.,andOlkkonenV.M.(2001)GenomeBiol.2:3007.1-3007.7.
2.TakaiY.,etal.(2001)Physiol.Rev.8:,153-208.
3.AliB.R.,etal.(2004)J.CellSci.117:6401-6412.
4.ZerialM.,andMcBrideH.(2001)Nat.Rev.Mol.CellBiol.2:107-117.
5.SonnichsenB.,etal.(2000)J.CellBiol.149:901-913
6.WoodmanP.G.(2000)Traffic.1:695-701.

ProductImages

<p>SDS-PAGE of 26kDa human Rab5 protein (SPR-121).</p>

SDS-PAGEof26kDahumanRab5protein(SPR-121).

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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。