4000-520-616
欢迎来到免疫在线！(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
产品库 品牌馆 现货促销 技术交流 新闻动态 联系我们
StressMarq Biosciences
主营：主营：抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
咨询热线电话
4000-520-616
公司首页 公司介绍 产品中心 新闻动态 联系方式 在线下单
当前位置： 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Rab5 Protein/SPR-121A/50-µg
商品详细StressMarq/Rab5 Protein/SPR-121A/50-µg
StressMarq/Rab5 Protein/SPR-121A/50-µg
StressMarq/Rab5 Protein/SPR-121A/50-µg
商品编号： SPR-121A
市场价： ¥8340.00
美元价： 5004.00
产地： 美国(厂家直采)
公司：
产品分类： 酸碱缓冲液
公司分类： acid_base_buffer_solution
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
立即询价
商品介绍

Overview:

Product Name Rab5 Protein
Description

Human Recombinant Rab5 Protein

Applications WB, SDS-PAGE
Concentration Lot/batch specific. See included datasheet.
Conjugates His tag

Properties

Storage Buffer 20mM Tris/HCl pH7.5, 0.45M NaCl, 10% glycerol, 0.5mM DTT
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Affinity Purified
Specificity ~26 kDa
Cite This Product Human Recombinant Rab5 Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-121)
Certificate of Analysis This product has been certified >90% pure using SDS-PAGE analysis.

Biological Description

Alternative Names Rab 5A Protein, RAS associated protein RAB5A Protein, Ras related protein Rab 5 A Protein
Research Areas Cancer, Heat Shock
Cellular Localization Cell membrane, Early Endosome Membrane, Melanosome
Accession Number BC001267
Gene ID 5868
Swiss Prot P20339
Scientific Background Rab5 is a 24kDa member of the Rab family of small guanosine triphosphatases (GTPases), Ras superfamily. Rab GTPases are central regulators of membrane trafficking in the eukaryotic cell. Their regulatory capacity depends on their ability to cycle between the GDP -bound inactive and GTP-bound active states. This conversion is regulated by GDP/GTP exchange factors (GEPs), GDP dissociation inhibitors (GDIs) and GTPase-activating proteins (GAPs) (1, 2). Activation of a Rab protein is coupled to its association with intracellular membranes, allowing it to recruit downstream effector proteins to the cytoplasmic surface of a subcellular compartment (3). Through these proteins, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion(1). Rab proteins contain conserved regions involved in guanine-nucleotide binding, and hyper variable COHO-terminal domains with a cysteine motif implicated in subcellular targeting. Post-translational modification of the cysteine motif with one or two geranyl groups is essential for the membrane association and correct intracellular localization of Rab proteins(3). Each Rab shows a characteristic subcellular distribution (4). In particular, Rab5 is ubiquitously expressed in human tissues. It localizes mainly to early endosomes, but is also present on the plasma membrane. It regulates the fusion between endocytic vesicles and early endosomes, as well as the homotypic fusion between early endosomes (5). Among the proteins recruited by the GTP-bound active Rab5 are Rabaptin-5 and EEA1 (6). Anti-Rab5 may be used as an early endosome marker.
References 1. Stenmark H., and Olkkonen V.M. (2001) Genome Biol. 2: 3007.1-3007.7.
2. Takai Y., et al. (2001) Physiol. Rev. 8:, 153-208.
3. Ali B.R., et al. (2004) J. Cell Sci. 117: 6401-6412.
4. Zerial M., and McBride H. (2001) Nat. Rev. Mol. Cell Biol. 2: 107-117.
5. Sonnichsen B., et al. (2000) J. Cell Biol. 149: 901-913
6. Woodman P.G. (2000) Traffic. 1: 695-701.

Product Images

<p>SDS-PAGE of 26kDa human Rab5 protein (SPR-121).</p>

SDS-PAGE of 26kDa human Rab5 protein (SPR-121).

Product Citations (0)

Currently there are no citations for this product.

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
品牌分类
CLIA套件 兴奋剂 敌手 抑制剂 蛋白质 活化剂 抗氧化剂 氧化还原探针 多克隆
显示分类
联络我们
服务热线：4000-520-616
（限工作日9:00-18:00）
QQ ：1570468124
手机：18915418616
快速导航：
总部地址：
江苏省苏州市工业园区星湖街218号 苏州生物医药产业园一期（生物纳米园）A4-216(邮编：215125)
工作时间：周一至周五9:00~18:00
技术支持：
短信：18915418616
服务热线：
4000-520-616（全国）
☏  0512-67156496（苏州）
版权信息：
©  2015-2022 苏州蚂蚁淘生物科技有限公司 版权所有 中国
网站备案：
友情链接：
免责声明：
本站有部分内容来自互联网，如无意中侵犯了某个媒体 、公司 、企业或个人等的知识产权，请来电或致函告之，
本网站将在规定时间内给予删除等相关处理。
扫描二维码关注官方微信
获取最新促销及产品信息