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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-PKC zeta Antibody (pThr410)/SPC-1062D-A680/100-µl
商品详细StressMarq/Anti-PKC zeta Antibody (pThr410)/SPC-1062D-A680/100-µl
StressMarq/Anti-PKC zeta Antibody (pThr410)/SPC-1062D-A680/100-µl
StressMarq/Anti-PKC zeta Antibody (pThr410)/SPC-1062D-A680/100-µl
商品编号: SPC-1062D-A680
市场价: ¥6840.00
美元价: 4104.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNamePKCzetaAntibody(pThr410)
Description

RabbitAnti-HumanPKCzeta(pThr410)Polyclonal

SpeciesReactivityHuman
ApplicationsWB,AM
AntibodyDilutionWB(1:250);optimaldilutionsforassaysshouldbedeterminedbytheuser.
HostSpeciesRabbit
ImmunogenSpeciesHuman
ImmunogenAphospho-specificpeptidecorrespondingtoresiduessurroundingThr410ofhumanPKCzeta(AA407-413)
ConjugatesAlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBufferPBSpH7.4,50%glycerol,0.025%Thimerosal
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationPeptideAffinityPurified
ClonalityPolyclonal
SpecificityDetects67.718kDa.
CiteThisProductStressMarqBiosciencesCat#SPC-1062,RRID:AB_2709515
CertificateofAnalysisA1:250dilutionofSPC-1062wassufficientfordetectionofPKCzeta(pThr410)in10µgofHeLacelllysatebyECLimmunoblotanalysisusinggoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNamesPKC2Antibody,PKCZETAAntibody,PKC2Antibody,PKCZAntibody,PKCZETAAntibody,PKM-zeta,includedAntibody,PRKCZAntibody,ProteinkinaseCzetaAntibody,ProteinkinaseCzetaformAntibody,ProteinkinaseCzetatypeAntibody,r14-3-3Antibody,R74924Antibody,zetaPKCAntibody,14-3-3-zetaisoformAntibody,AI098070Antibody,aPKCzetaAntibody,C80388Antibody,EC2.7.11.13Antibody,KPCZ_HUMANAntibody,nPKCzetaAntibody,nPKC-zetaAntibody,OTTHUMP00000001368Antibody,OTTHUMP00000044160Antibody
CellularLocalizationCytoplasm,CellJunction,Endosome
AccessionNumberNP_002735
GeneID5590
SwissProtQ05513
ScientificBackgroundCalcium-anddiacylglycerol-independentserine/threonine-proteinkinasethatfunctionsinphosphatidylinositol3-kinase(PI3K)pathwayandmitogen-activatedprotein(MAP)kinasecascade,andisinvolvedinNF-kappa-Bactivation,mitogenicsignaling,cellproliferation,cellpolarity,inflammatoryresponseandmaintenanceoflong-termpotentiation(LTP).Uponlipopolysaccharide(LPS)treatmentinmacrophages,orfollowingmitogenicstimuli,functionsdownstreamofPI3KtoactivateMAP2K1/MEK1-MAPK1/ERK2signalingcascadeindependentlyofRAF1activation.Requiredforinsulin-dependentactivationofAKT3,butmayfunctionasanadapterratherthanadirectactivator.UponinsulintreatmentmayactasadownstreameffectorofPI3KandcontributetotheactivationoftranslocationoftheglucosetransporterSLC2A4/GLUT4andsubsequentglucosetransportinADIpocytes.InEGF-inducedcells,bindsandactivatesMAP2K5/MEK5-MAPK7/ERK5independentlyofitskinaseactivityandcanactivateJUNpromoterthroughMEF2C.ThroughbindingwithSQSTM1/p62,functionsininterleukin-1signalingandactivationofNF-kappa-BwiththespecificadaptersRIPK1andTRAF6.ParticipatesinTNF-dependenttransactivationofNF-kappa-BbyphosphorylatingandactivatingIKBKBkinase,whichinturnleadstothedegradationofNF-kappa-Binhibitors.Inmigratingastrocytes,formsacytoplasmiccomplexwithPARD6AandisrecruitedbyCDC42tofunctionintheestablishmentofcellpolarityalongwiththemicrotubulemotoranddynein.InassociationwithFEZ1,stimulatesneuronaldifferentiationinPC12cells.Ininflammatoryresponse,isrequiredfortheT-helper2(Th2)differentiationprocess,includinginterleukinsproduction,efficientactivationofJAK1andthesubsequentphosphorylationandnucleartranslocationofSTAT6.Maybeinvolvedindevelopmentofallergicairwayinflammation(asthma),aprocessdependentonTh2immuneresponse.InNF-kappa-B-mediatedinflammatoryresponse,canrelievetheSETD6-dependentrepressionofNF-kappa-BtargetgenesbyphosphorylatingtheRELAsubunitat"Ser-311".IsnecessaryandsufficientforLTPmaintenanceinhippocampalCA1pyramidalcells.

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 ATTO680
Overview:
  • Highfluorescenceyield
  • ExcellentthermalandphotostABIlity
  • Quenchedbyelectrondonors
  • Veryhydrophilic
  • Goodsolubilityinpolarsolvents
  • Zwitterionicdye
  • MolarMass:631g/mol

ATTO680Datasheet

 ATTO 680 Fluorophore Absorption and Emission SpectrumOpticalProperties:

λex =680nm

λem=700 nm

εmax=1.25×105

Φf= 0.30

τfl =1.7ns

Brightness=37.5

Laser =633 –676nm

Filterset =Cy®5.5

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。