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当前位置： 首页 > 产品中心 > Other_buffers > StressMarq/Anti-PKC alpha Antibody (pThr497)/SPC-1055D-BI/100-µl
商品详细StressMarq/Anti-PKC alpha Antibody (pThr497)/SPC-1055D-BI/100-µl
StressMarq/Anti-PKC alpha Antibody (pThr497)/SPC-1055D-BI/100-µl
StressMarq/Anti-PKC alpha Antibody (pThr497)/SPC-1055D-BI/100-µl
商品编号： SPC-1055D-BI
市场价： ¥6760.00
美元价： 4056.00
产地： 美国(厂家直采)
公司：
产品分类： 其它缓冲液
公司分类： Other_buffers
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

ProductNamePKCalphaAntibody(pThr497)
Description

RabbitAnti-HumanPKCalpha(pThr497)Polyclonal

SpeciesReactivityHuman
ApplicationsWB,AM
AntibodyDilutionWB(1:250);optimaldilutionsforassaysshouldbedeterminedbytheuser.
HostSpeciesRabbit
ImmunogenSpeciesHuman
ImmunogenAphospho-specificpeptidecorrespondingtoresiduessurroundingThr497ofhumanPKCAlpha(AA494-500)
ConjugatesAlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBufferPBSpH7.4,50%glycerol,0.025%Thimerosal
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationPeptideAffinityPurified
ClonalityPolyclonal
SpecificityDetects76.764kDa.
CiteThisProductStressMarqBiosciencesCat#SPC-1055,RRID:AB_2709389
CertificateofAnalysisA1:250dilutionofSPC-1055wassufficientfordetectionofPKCalpha(pThr497)in10µgofHeLacelllysatebyECLimmunoblotanalysisusinggoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNamesPKC-AAntibody,PKC-alphaAntibody,PKCAAntibody,PRKACAAntibody,PRKCAAntibody,ProteinKinaseCalphaAntibody,ProteinkinaseCalphatypeAntibody,AAG6Antibody,Agingassociatedgene6Antibody,aPKCAntibody,KPCA_HUMANAntibody,
CellularLocalizationCytoplasm,Cellmembrane,Mitochondrion,Mitochondrionmembrane,Nucleus
AccessionNumberNP_002728
GeneID5578
SwissProtP17252
ScientificBackgroundCalcium-activated,phospholipid-anddiacylglycerol(DAG)-dependentserine/threonine-proteinkinasethatisinvolvedinpositiveandnegativeregulationofcellproliferation,apoptosis,differentiation,migrationandadhesion,tumourigenesis,cardiachypertrophy,angiogenesis,plateletfunctionandinflammation,bydirectlyphosphorylatingtargetssuchasRAF1,BCL2,CSPG4,TNNT2/CTNT,oractivatingsignalingcascadeinvolvingMAPK1/3(ERK1/2)andRAP1GAP.Involvedincellproliferationandcellgrowtharrestbypositiveandnegativeregulationofthecellcycle.CanpromotecellgrowthbyphosphorylatingandactivatingRAF1,whichmediatestheactivationoftheMAPK/ERKsignalingcascade,and/orbyup-regulatingCDKN1A,whichfacilitatesactivecyclin-dependentkinase(CDK)complexformationingliomacells.InintestinalcellsstimulatedbythephorbolesterPMA,cantriggeracellcyclearrestprogramwhichisassociatedwiththeaccumulationofthehyper-phosphorylatedgrowth-suppressiveformofRB1andinductionoftheCDKinhibitorsCDKN1AandCDKN1B.Exhibitsanti-apoptoticfunctioningliomacellsandprotectsthemfromapoptosisbysuppressingthep53/TP53-mediatedactivationofIGFBP3,andinleukemiacellsmediatesanti-apoptoticactionbyphosphorylatingBCL2.Duringmacrophagedifferentiationinducedbymacrophagecolony-stimulatingfactor(CSF1),istranslocatedtothenucleusandisassociatedwithmacrophagedevelopment.Afterwounding,translocatesfromfocalcontactstolamellipodiaandparticipatesinthemodulationofdesmosomaladhesion.PlaysaroleincellmotilitybyphosphorylatingCSPG4,whichinducesassociationofCSPG4withextensivelamellipodiaatthecellperipheryandpolarizationofthecellaccompaniedbyincreasesincellmotility.Ishighlyexpressedinanumberofcancercellswhereitcanactasatumourpromoterandisimplicatedinmalignantphenotypesofseveraltumourssuchasgliomasandbreastcancers.Negativelyregulatesmyocardialcontractilityandpositivelyregulatesangiogenesis,plateletaggregationandthrombusformationinarteries.Mediateshypertrophicgrowthofneonatalcardiomyocytes,inpartthroughaMAPK1/3(ERK1/2)-dependentsignalingpathway,anduponPMAtreatment,isrequiredtoinducecardiomyocytehypertrophyuptoheartfailureanddeath,byincreasingproteinsynthesis,protein-DNAratioandcellsurfacearea.RegulatescardiomyocytefunctionbyphosphorylatingcardiactroponinT(TNNT2/CTNT),whichinducessignificantreductioninactomyosinATPaseactivity,myofilamentcalciumsensitivityandmyocardialcontractility.Inangiogenesis,isrequiredforfullendothelialcellmigration,adhesiontovitronectin(VTN),andvascularendothelialgrowthfactorA(VEGFA)-dependentregulationofkinaseactivationandvasculartubeformation.InvolvedinthestABIlizationofVEGFAmRNAatpost-transcriptionallevelandmediatesVEGFA-inducedcellproliferation.Intheregulationofcalcium-inducedplateletaggregation,mediatessignalsfromtheCD36/GP4receptorforgranulerelease,andactivatestheintegrinheterodimerITGA2B-ITGB3throughtheRAP1GAPpathwayforadhesion.Duringresponsetolipopolysaccharides(LPS),mayregulateselectiveLPS-inducedmacrophagefunctionsinvolvedinhostdefenseandinflammation.Butinsomeinflammatoryresponses,maynegativelyregulateNF-kappa-B-inducedgenes,throughIL1A-dependentinductionofNF-kappa-Binhibitoralpha(NFKBIA/IKBA).Uponstimulationwith12-O-tetradecanoylphorbol-13-acetate(TPA),phosphorylatesEIF4G1,whichmodulatesEIF4G1bindingtoMKNK1andmaybeinvolvedintheregulationofEIF4Ephosphorylation.PhosphorylatesKIT,leADIngtoinhibitionofKITactivity.

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BiotinBiotin Conjugate Structure

Properties:

  • BindstetramericavidinproteinsincludingStreptavidinandneuravidinwithveryhighaffinity
  • Molarmass:244.31g/mol
  • Formula:C10H16N2O3S
  • Applications:Westernblot,immunohistochemistry,andELISA

BiotinDatasheet

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
品牌分类
CLIA套件 兴奋剂 敌手 抑制剂 蛋白质 活化剂 抗氧化剂 氧化还原探针 多克隆
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