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当前位置: 首页 > 产品中心 > Other_buffers > StressMarq/Anti-PINX1 Antibody/SPC-1330D-FITC/100-µl
商品详细StressMarq/Anti-PINX1 Antibody/SPC-1330D-FITC/100-µl
StressMarq/Anti-PINX1 Antibody/SPC-1330D-FITC/100-µl
StressMarq/Anti-PINX1 Antibody/SPC-1330D-FITC/100-µl
商品编号: SPC-1330D-FITC
市场价: ¥5880.00
美元价: 3528.00
产地: 美国(厂家直采)
公司:
产品分类: 其它缓冲液
公司分类: Other_buffers
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNamePINX1Antibody
Description

RabbitAnti-HumanPINX1Polyclonal

SpeciesReactivityHuman
ApplicationsIHC,ELISA
AntibodyDilutionIHC(1:100),ELISA(1:20000);optimaldilutionsforassaysshouldbedeterminedbytheuser.
HostSpeciesRabbit
ImmunogenSpeciesHuman
ImmunogenSynthesizedpeptidederivedfrominternalofhumanPINX1.
ConjugatesAlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBufferPBSpH7.4,50%glycerol,150mMNaCl,0.02%sodiumazide
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationAffinityPurified
ClonalityPolyclonal
IsotypeIgG
SpecificityDetectsendogenouslevelsoftotalPINX1protein.
CiteThisProductStressMarqBiosciencesCat#SPC-1330,RRID:AB_2713727
CertificateofAnalysisA1:100dilutionofSPC-1330wassufficientfordetectionofPINX1inhumanhearttissueusingGoatAnti-RabbitIgGasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNames67-11-3proteinantibody,FLJ20565antibody,Hepatocellularcarcinoma-relatedputativetumorsuppressorantibody,Liver-relatedputativetumorsuppressorantibody,LPTLantibody,LPTSantibody,MGC8850antibody,OTTHUMP00000224984antibody,OTTHUMP00000224985antibody,OTTHUMP00000224986antibody,OTTHUMP00000225053antibody,OTTHUMP00000225054antibody,PIN2interactingprotein1antibody,Pin2-interactingproteinX1antibody,PIN2/TERF1-interactingtelomeraseinhibitor1antibody,PINX1antibody,PINX1_HUMANantibody,Protein67-11-3antibody,TRF1-interactingprotein1antibody
CellularLocalizationChromosome,Nucleus
AccessionNumberNP_060354.4
GeneID54984
SwissProtQ96BK5
ScientificBackgroundPIN2/TERF1-interactingtelomeraseinhibitor1,alsoknownasPINX1,isahumangene.ItmediatesTRF1andTERTaccumulationinnucleolusandenhancesTRF1bindingtotelomeres,inhibitstelomeraseactivity.itmayalsoinhibitcellproliferationandactastumorsuppressor.Over-expressionofPINX1resultsindecreasedtelomeraseactivity,telomereshortening,andinductionofcrisis.ReductionofPINX1leadstoanincreaseintelomeraseactivityandelongationoftelomeres.PINX1differsfromotherproteinsthatregulatetelomerelengthinthatitactsontelomerasewhileotherproteinsadjusttelomerelengthwithoutaffectingtelomeraseactivity.
References1.SongH.etal.(2004)Biochem.Biophys.Res.Commun.(UnitedStates)316(4):1116–23.
2.Soohoo,C.Y.(2010)JournalofBiologicalChemistry.
3.Yoo,J.E.(2009)JournalofMolecularBiology.
4.Zhou,X.Z.(2011)JournalofClinicalInvestigation.

ProductImages

<p>Immunohistochemistry analysis using Rabbit Anti-PINX1 Polyclonal Antibody (SPC-1330). Tissue: Heart Tissue. Species: Human. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-PINX1 Polyclonal Antibody (SPC-1330) at 1:100. The image on the right is treated with the synthesized peptide.</p>

ImmunohistochemistryanalysisusingRabbitAnti-PINX1PolyclonalAntibody(SPC-1330).Tissue:HeartTissue.Species:Human.Fixation:Formalinfixedparaffin-embedded.PrimaryAntibody:RabbitAnti-PINX1PolyclonalAntibody(SPC-1330)at1:100.Theimageontherightistreatedwiththesynthesizedpeptide.

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 FITC(Fluorescein)
Overview:
  • Excellentfluorescencequantumyield
  • Highrateofphotobleaching
  • Goodsolubilityinwater
  • Broademissionspectrum
  • pHdependentspectra
  • Molecularformula:C20H12O5
  • Molarmass:332.3g/mol

FITC-Fluorescent-conjugate

FITC Fluorescein Fluorophore Excitation and Emission SpectraOpticalProperties:

λex =494 nm

λem=520 nm

εmax=7.3×104

Φf= 0.92

τfl =5.0ns

Brightness= 67.2

Laser = 488 nm

Filterset = FITC

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。