StressMarq/Pifithrin mu/SIH-325-50MG/50-mg
商品编号：
SIH-325-50MG
市场价：
¥2980.00
美元价：
1788.00
产品分类：
其它缓冲液
公司分类：
Other_buffers
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Pifithrinmu |
| Description | Hsp70inhibitor |
| Purity | >98% |
| CASNo. | 64984-31-2 |
| MolecularFormula | C8H7NO2S |
| MolecularWeight | 181.2 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | Solubleinethanol(110mM)andinDMSO(110mM) |
| Source | Synthetic |
| Appearance | Whitetooff-whitesolid |
| SMILES | C1=CC=C(C=C1)C#CS(=O)(=O)N |
| InChI | InChI=1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11) |
| InChIKey | ZZUZYEMRHCMVTB-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionS24/25-AvoidcontactwithskinandeyesHazardPhrases:H302-H315-H319-H335PrecautionaryPhrases:P261-P305+P351+P338 |
| CiteThisProduct | Pifithrinmu(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-325) |
BIOLOGicalDescription
| AlternativeNames | 2-Phenylethynesulfonamide,PFTµ |
| ResearchAreas | Cancer,HeatShock |
| PubChemID | 327653 |
| ScientificBackground | SelectivelyinteractswithHSP70anddisruptsitsassociationwithco-chaperonesandsubstrateproteins.Itinducesapoptosisandiscellpermeable.Also,inhibitsp53bindingtomitochondriabyreducingitsaffinityforantiapoptoticproteinsBcl-2andBcl-XL.LookingformoreinformationonHSP70?VisitournewHSP70ScientificResourceGuideathttp://www.HSP70.com. |
| References | 1. LeuJ.L.,etal.(2009)Mol.Cell.36:15. |
ProductImages
ChemicalstructureofPifithrinmu(SIH-325),aHsp70inhibitor.CAS#:64984-31-2.MolecularFormula:C8H7NO2S.MolecularWeight:181.2g/mol.
ProductCitations(2)
OtherCitations
AS-2,anovelinhibitorofp53-dependentapoptosis,preventsapoptoticmitochondrialdysfunctioninatranscription-independentmannerandprotectsmicefromalethaldoseofionizingrADIation.
Morita,A.etal.(2014)BiochemBiophysResCommun.450(4):1498-504.
PubMedID:25026551Applications:Invitroinhibition
HSP70andHSP90DifferentiallyRegulateTranslocationofExtracellularAntigentotheCytosolforCross-Presentation.
Kato.Y.etal.(2012)AutoimmuneDis.2012:745962.
PubMedID:23050124Applications:HSP70inhibitorassay
品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
