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当前位置: 首页 > 产品中心 > Other_buffers > StressMarq/Picropodophyllotoxin/SIH-467-25MG/25-mg
商品详细StressMarq/Picropodophyllotoxin/SIH-467-25MG/25-mg
StressMarq/Picropodophyllotoxin/SIH-467-25MG/25-mg
StressMarq/Picropodophyllotoxin/SIH-467-25MG/25-mg
商品编号: SIH-467-25MG
市场价: ¥8900.00
美元价: 5340.00
产地: 美国(厂家直采)
公司:
产品分类: 其它缓冲液
公司分类: Other_buffers
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNamePicropodophyllotoxin
Description

IGF1Rinhibitor

Purity>96%(HPLC)
CASNo.477-47-4
MolecularFormulaC22H22O8
MolecularWeight414.4

Properties

StorageTemperature-20ºC
ShippingTemperatureShippedAmbient
ProductTypeInhibitor
SolubilitySolubleinDMSO(10mg/ml,warm)ordimethylformamide(25mg/ml)
SourceSynthetic
AppearanceWhitesolid
SMILES[[email protected]]25[[email protected]]([[email protected]@H](C1=CC3=C(C=C1[[email protected]@H]2O)OCO3)C4=CC(=C(C(=C4)OC)OC)OC)C(OC5)=O
InChIInChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1
InChIKeyYJGVMLPVUAXIQN-HAEOHBJNSA-N
SafetyPhrasesClassification:Acutetoxicity,Oral(Category3),H301Acutetoxicity,Dermal(Category4),H312Skinirritation(Category2),H315Eyeirritation(Category2A),H319Specifictargetorgantoxicity-singleexposure(Category3),Respiratorysystem,H335SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H301Toxicifswallowed.H312Harmfulincontactwithskin.H315Causesskinirritation.H319Causesseriouseyeirritation.H335Maycauserespiratoryirritation.Precautionarystatements:P261Avoidbreathingdust/fume/gas/mist/vapours/spray.P264Washskinthoroughlyafterhandling.P270Donoteat,drinkorsmokewhenusingthisproduct.P271Useonlyoutdoorsorinawell-ventilatedareaP280Wearprotectivegloves/eyeprotection/faceprotection.P301+P310IFSWALLOWED:ImmediatelycallaPOISONCENTERordoctor/physician.P302+P352IFONSKIN:Washwithplentyofsoapandwater.P304+P340IFINHALED:Removevictimtofreshairandkeepatrestinapositioncomfortableforbreathing.P305+P351+P338IFINEYES:Rinsecautiouslywithwaterforseveralminutes.Removecontactlenses,ifpresentandeasytodo.Continuerinsing.P312CallaPOISONCENTERordoctor/physicianifyoufeelunwell.P322Specificmeasures(seesupplementalfirstaidinstructionsonthislabel).P330Rinsemouth.P332+P313Ifskinirritationoccurs:Getmedicaladvice/attention.P337+P313Ifeyeirritationpersists:Getmedicaladvice/attention.P362Takeoffcontaminatedclothingandwashbeforereuse.P403+P233Storeinawell-ventilatedplace.Keepcontainertightlyclosed.P405Storelockedup.P501Disposeofcontents/containertoanapprovedwastedisposalplant.
CiteThisProductPicropodophyllotoxin(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-467)

BIOLOGicalDescription

AlternativeNamesPicropodophyllin,NSC36407,PPP,(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3",4":6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
ResearchAreasCellSignaling
PubChemID72435
ScientificBackgroundPicropodophyllotoxinisaninhibitorofinsulin-likegrowthfactor1receptor(IGF1R).Specifically,itinhibitsIGF1Rautophosphorylation.IthasalsobeenseentoincreasesthefractionofcellsintheG2/Mphase,reducepAKTandpERK1/2,andupregulatesapoptosis.Picropodophyllotoxinexhibitsantiproliferativeeffectsinmultiplecancercelllines.
References1.GirnitaA.,etal.(2004)CancerRes.64(1):236–242.
2.StrömbergT.,etal.(2006)Blood.107(2):669–678.

ProductImages

<p>Chemical structure of Picropodophyllotoxin (SIH-467), a IGF1R inhibitor. CAS #: 477-47-4. Molecular Formula: C22H22O8. Molecular Weight: 414.4 g/mol.</p>

ChemicalstructureofPicropodophyllotoxin(SIH-467),aIGF1Rinhibitor.CAS#:477-47-4.MolecularFormula:C22H22O8.MolecularWeight:414.4g/mol.

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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。