StressMarq/Picropodophyllotoxin/SIH-467-5MG/5-mg
商品编号：
SIH-467-5MG
市场价：
¥2240.00
美元价：
1344.00
产品分类：
其它缓冲液
公司分类：
Other_buffers
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Picropodophyllotoxin |
| Description | IGF1Rinhibitor |
| Purity | >96%(HPLC) |
| CASNo. | 477-47-4 |
| MolecularFormula | C22H22O8 |
| MolecularWeight | 414.4 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO(10mg/ml,warm)ordimethylformamide(25mg/ml) |
| Source | Synthetic |
| Appearance | Whitesolid |
| SMILES | [[email protected]]25[[email protected]]([[email protected]@H](C1=CC3=C(C=C1[[email protected]@H]2O)OCO3)C4=CC(=C(C(=C4)OC)OC)OC)C(OC5)=O |
| InChI | InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1 |
| InChIKey | YJGVMLPVUAXIQN-HAEOHBJNSA-N |
| SafetyPhrases | Classification:Acutetoxicity,Oral(Category3),H301Acutetoxicity,Dermal(Category4),H312Skinirritation(Category2),H315Eyeirritation(Category2A),H319Specifictargetorgantoxicity-singleexposure(Category3),Respiratorysystem,H335SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H301Toxicifswallowed.H312Harmfulincontactwithskin.H315Causesskinirritation.H319Causesseriouseyeirritation.H335Maycauserespiratoryirritation.Precautionarystatements:P261Avoidbreathingdust/fume/gas/mist/vapours/spray.P264Washskinthoroughlyafterhandling.P270Donoteat,drinkorsmokewhenusingthisproduct.P271Useonlyoutdoorsorinawell-ventilatedareaP280Wearprotectivegloves/eyeprotection/faceprotection.P301+P310IFSWALLOWED:ImmediatelycallaPOISONCENTERordoctor/physician.P302+P352IFONSKIN:Washwithplentyofsoapandwater.P304+P340IFINHALED:Removevictimtofreshairandkeepatrestinapositioncomfortableforbreathing.P305+P351+P338IFINEYES:Rinsecautiouslywithwaterforseveralminutes.Removecontactlenses,ifpresentandeasytodo.Continuerinsing.P312CallaPOISONCENTERordoctor/physicianifyoufeelunwell.P322Specificmeasures(seesupplementalfirstaidinstructionsonthislabel).P330Rinsemouth.P332+P313Ifskinirritationoccurs:Getmedicaladvice/attention.P337+P313Ifeyeirritationpersists:Getmedicaladvice/attention.P362Takeoffcontaminatedclothingandwashbeforereuse.P403+P233Storeinawell-ventilatedplace.Keepcontainertightlyclosed.P405Storelockedup.P501Disposeofcontents/containertoanapprovedwastedisposalplant. |
| CiteThisProduct | Picropodophyllotoxin(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-467) |
BIOLOGicalDescription
| AlternativeNames | Picropodophyllin,NSC36407,PPP,(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3",4":6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one |
| ResearchAreas | CellSignaling |
| PubChemID | 72435 |
| ScientificBackground | Picropodophyllotoxinisaninhibitorofinsulin-likegrowthfactor1receptor(IGF1R).Specifically,itinhibitsIGF1Rautophosphorylation.IthasalsobeenseentoincreasesthefractionofcellsintheG2/Mphase,reducepAKTandpERK1/2,andupregulatesapoptosis.Picropodophyllotoxinexhibitsantiproliferativeeffectsinmultiplecancercelllines. |
| References | 1.GirnitaA.,etal.(2004)CancerRes.64(1):236–242. 2.StrömbergT.,etal.(2006)Blood.107(2):669–678. |
ProductImages
ChemicalstructureofPicropodophyllotoxin(SIH-467),aIGF1Rinhibitor.CAS#:477-47-4.MolecularFormula:C22H22O8.MolecularWeight:414.4g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
