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当前位置: 首页 > 产品中心 > Other_buffers > StressMarq/Anti-PDGFR alpha Antibody (pTyr768)/SPC-1049D-RPE/100-µl
商品详细StressMarq/Anti-PDGFR alpha Antibody (pTyr768)/SPC-1049D-RPE/100-µl
StressMarq/Anti-PDGFR alpha Antibody (pTyr768)/SPC-1049D-RPE/100-µl
StressMarq/Anti-PDGFR alpha Antibody (pTyr768)/SPC-1049D-RPE/100-µl
商品编号: SPC-1049D-RPE
市场价: ¥6780.00
美元价: 4068.00
产地: 美国(厂家直采)
公司:
产品分类: 其它缓冲液
公司分类: Other_buffers
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNamePDGFRalphaAntibody(pTyr768)
Description

RabbitAnti-HumanPDGFRalpha(pTyr768)Polyclonal

SpeciesReactivityHuman
ApplicationsWB,AM
AntibodyDilutionWB(1:250);optimaldilutionsforassaysshouldbedeterminedbytheuser.
HostSpeciesRabbit
ImmunogenSpeciesHuman
ImmunogenAphospho-specificpeptidecorrespondingtoresiduessurroundingTyr768ofhumanPDGFRAlpha(AA765-771)
ConjugatesAlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBufferPBSpH7.4,50%glycerol,0.025%Thimerosal
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationPeptideAffinityPurified
ClonalityPolyclonal
SpecificityDetects122.67kDa.
CiteThisProductStressMarqBiosciencesCat#SPC-1049,RRID:AB_2709281
CertificateofAnalysisA1:250dilutionofSPC-1049wassufficientfordetectionofPDGFRalpha(pTyr768)in10µgof293TcelllysatebyECLimmunoblotanalysisusinggoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNamesPDGFalphachainAntibody,PDGFReceptoralphaAntibody,PDGF-R-alphaAntibody,PDGFR2Antibody,PDGFRalphaAntibody,PDGFR-alphaAntibody,PDGFR2Antibody,PDGFRAAntibody,PDGFR-AAntibody,PDGFRA/BCRfusionAntibody,PGFRA_HUMANAntibody,Plateletderivedgrowthfactorreceptor2Antibody,PlateletderivedgrowthfactorreceptoralphaAntibody,PlateletderivedgrowthfactorreceptoralphapolypeptideAntibody,PlateletderivedgrowthfactorreceptorAntibody,Alpha-typeplatelet-derivedgrowthfactorreceptorAntibody,CD140antigen-likefamilymemberAAntibody,CD140aAntibody,CD140aantigenAntibody,MGC74795Antibody,RearrangedinhypereosinophiliaplateletderivedgrowthfactorreceptoralphafusionproteinAntibody,RHEPDGFRAAntibody
CellularLocalizationCellmembrane,Nucleus
AccessionNumberNP_006197
GeneID5156
SwissProtP16234
ScientificBackgroundPDGFRAisareceptor-tyrosinekinasethatisactivateduponbindingplatelet-derivedgrowthfactor(PDGF).LigandbindingcausesdimerizationofthereceptortoactivatesignallingcascadestoactivateeffectorsubstratessuchasPIK3R1,PLCG1,andPTPN11.Effectorsubstrateswillcausereleaseofcalciumfromendoplasmicreticulum,byPLCG1,andactivationofAKT1,byPIK3R1.ThisultimatelyleadstogrowthandproliferationincellsbytheMAPKandSTATtranscriptionfactoractivation.PDGFRAisnegativelyregulatedbyproteinphosphatasestocauseinactivationandinternalization.DuetoPDGFRA"sroleincellulargrowthitsdysfunctionmayleadtumourigenesis.AhighnumberofgastrointestinalstromaltumourshavebeenimplicatedinPDGFRAdysfunctionandconstitutiveactivation.Typicallymis-senseordeletionmutationswerefoundtocauseconstitutivelyactivatedPDGFRA.FurThermore,afusionproteinofPDGFRAwithBCRcanarisefromatranslocationeventwiththePDGFRAgenelocus.Thisfusionproteinhasbeenimplicatedinthedevelopmentofchronicmyeloidleukemias.

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 R-PE(R-Phycoerythrin)
Overview:
  • Broadexcitationspectrum
  • Highquantumyield
  • Photostable
  • Memberofthephycobiliproteinfamily
  • Isolatedfromredalgae
  • Excellentsolubilityinwater
  • MolecularWeight:250kDa

R-PEDatasheet

 R-PE Fluorophore Excitation and Emission SpectraOpticalProperties:

λex =565nm

λem=575nm

εmax=2.0×106

Φf= 0.84

Brightness=1.68x103

Laser = 488to561nm

Filterset = TRITC

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。