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当前位置: 首页 > 产品中心 > Other_buffers > StressMarq/Anti-PDGFR alpha Antibody/SPC-1183D-A390/100-µl
商品详细StressMarq/Anti-PDGFR alpha Antibody/SPC-1183D-A390/100-µl
StressMarq/Anti-PDGFR alpha Antibody/SPC-1183D-A390/100-µl
StressMarq/Anti-PDGFR alpha Antibody/SPC-1183D-A390/100-µl
商品编号: SPC-1183D-A390
市场价: ¥6860.00
美元价: 4116.00
产地: 美国(厂家直采)
公司:
产品分类: 其它缓冲液
公司分类: Other_buffers
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNamePDGFRalphaAntibody
Description

RabbitAnti-HumanPDGFRalphaPolyclonal

SpeciesReactivityHuman,Mouse
ApplicationsWB,AM
AntibodyDilutionWB(1:250);optimaldilutionsforassaysshouldbedeterminedbytheuser.
HostSpeciesRabbit
ImmunogenSpeciesHuman
ImmunogenSyntheticpeptideofhumanPDGFRalpha(AA28-42)
ConjugatesAlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBufferPBSpH7.4,50%glycerol,0.025%Thimerosal
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationPeptideAffinityPurified
ClonalityPolyclonal
SpecificityDetects122.67kDa.
CiteThisProductStressMarqBiosciencesCat#SPC-1183,RRID:AB_2711675
CertificateofAnalysisA1:250dilutionofSPC-1183wassufficientfordetectionofPDGFRalphain10µgof293TcelllysatebyECLimmunoblotanalysisusinggoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNamesPDGFalphachainAntibody,PDGFReceptoralphaAntibody,PDGF-R-alphaAntibody,PDGFR2Antibody,PDGFRalphaAntibody,PDGFR-alphaAntibody,PDGFR2Antibody,PDGFRAAntibody,PDGFR-AAntibody,PDGFRA/BCRfusionAntibody,PGFRA_HUMANAntibody,Plateletderivedgrowthfactorreceptor2Antibody,PlateletderivedgrowthfactorreceptoralphaAntibody,PlateletderivedgrowthfactorreceptoralphapolypeptideAntibody,PlateletderivedgrowthfactorreceptorAntibody,Alpha-typeplatelet-derivedgrowthfactorreceptorAntibody,CD140antigen-likefamilymemberAAntibody,CD140aAntibody,CD140aantigenAntibody,MGC74795Antibody,RearrangedinhypereosinophiliaplateletderivedgrowthfactorreceptoralphafusionproteinAntibody,RHEPDGFRAAntibody
CellularLocalizationCellmembrane,Nucleus
AccessionNumberNP_006197
GeneID5156
SwissProtP16234
ScientificBackgroundPDGFRAisareceptor-tyrosinekinasethatisactivateduponbindingplatelet-derivedgrowthfactor(PDGF).LigandbindingcausesdimerizationofthereceptortoactivatesignallingcascadestoactivateeffectorsubstratessuchasPIK3R1,PLCG1,andPTPN11.Effectorsubstrateswillcausereleaseofcalciumfromendoplasmicreticulum,byPLCG1,andactivationofAKT1,byPIK3R1.ThisultimatelyleadstogrowthandproliferationincellsbytheMAPKandSTATtranscriptionfactoractivation.PDGFRAisnegativelyregulatedbyproteinphosphatasestocauseinactivationandinternalization.DuetoPDGFRA"sroleincellulargrowthitsdysfunctionmayleadtumourigenesis.AhighnumberofgastrointestinalstromaltumourshavebeenimplicatedinPDGFRAdysfunctionandconstitutiveactivation.Typicallymis-senseordeletionmutationswerefoundtocauseconstitutivelyactivatedPDGFRA.FurThermore,afusionproteinofPDGFRAwithBCRcanarisefromatranslocationeventwiththePDGFRAgenelocus.Thisfusionproteinhasbeenimplicatedinthedevelopmentofchronicmyeloidleukemias.

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 ATTO390
Overview:
  • Highfluorescenceyield
  • LargeStokes-shift(89nm)
  • GoodphotostABIlity
  • Moderatelyhydrophilic
  • Goodsolubilityinpolarsolvents
  • Coumarinderivate,uncharged
  • Lowmolarmass:343.42g/mol 

ATTO390Datasheet

ATTO 390 Fluorescent Dye Excitation and Emission SpectraOpticalProperties:

λex =390nm

λem=479nm

εmax=2.4×104

Φf= 0.90

τfl =5.0ns

Brightness= 21.6

Laser =365or405nm

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。