StressMarq/Anti-PAK4 Antibody (pSer474)/SPC-1044D-BI/100-µl-免疫在线蚂蚁淘旗下平台

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商品详细StressMarq/Anti-PAK4 Antibody (pSer474)/SPC-1044D-BI/100-µl

StressMarq/Anti-PAK4 Antibody (pSer474)/SPC-1044D-BI/100-µl

商品编号： SPC-1044D-BI

品牌： StressMarq Biosciences

市场价： ¥6760.00

美元价： 4056.00

产地：美国(厂家直采)

公司：

产品分类：其它缓冲液

公司分类： Other_buffers

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Overview:

ProductName PAK4Antibody(pSer474)

Description

RabbitAnti-HumanPAK4(pSer474)Polyclonal

SpeciesReactivity Human

Applications WB,AM

AntibodyDilution WB(1:250);optimaldilutionsforassaysshouldbedeterminedbytheuser.

HostSpecies Rabbit

ImmunogenSpecies Human

Immunogen Aphospho-specificpeptidecorrespondingtoresiduessurroundingSer474ofhumanPAK4(AA471-477)

Conjugates

AlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBuffer	PBSpH7.4,50%glycerol,0.025%Thimerosal
StorageTemperature	-20ºC
ShippingTemperature	BlueIceor4ºC
Purification	PeptideAffinityPurified
Clonality	Polyclonal
Specificity	Detects64.072kDa.
CiteThisProduct	StressMarqBiosciencesCat#SPC-1044,RRID:AB_2709191
CertificateofAnalysis	A1:250dilutionofSPC-1044wassufficientfordetectionofPAK4(pSer474)in10µgofHeLacelllysatebyECLimmunoblotanalysisusinggoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNames	PAK4Antibody,PAK-4Antibody,Pak4Antibody,PAK4_HUMANAntibody,ProteinkinaserelatedtoS.cerevisiaeSTE20effectorforCdc42HsAntibody,SerinethreoninekinasePAK4Antibody,Serine/threonineproteinkinasePAK4Antibody,Serine/threonineproteinkinasePAK4Antibody,Serine/threonine-proteinkinasePAK4Antibody,KIAA1142Antibody,p21activatedkinase4Antibody,p21Cdc42/Rac1-actiatedkinase4Antibody,P21protein(Cdc42/Rac)activatedkinase4Antibody,p21(CDKN1A)activatedkinase4Antibody,p21-activatedkinase4Antibody
CellularLocalization	Cytoplasm
AccessionNumber	NP_005875
GeneID	10298
SwissProt	O96013
ScientificBackground	Serine/threonineproteinkinasethatplaysaroleinavarietyofdifferentsignalingpathwaysincludingCytoskeletonregulation,cellmigration,growth,proliferationorcellsurvival.ActivationbyvariouseffectorsincludinggrowthfactorreceptorsoractiveCDC42andRAC1resultsinaconformationalchangeandasubsequentautophosphorylationonseveralserineand/orthreonineresidues.PhosphorylatesandinactivatestheproteinphosphataseSSH1,leADIngtoincreasedinhibitoryphosphorylationoftheactinbinding/depolymerizingfactorcofilin.DecreasedcofilinactivitymayleadtostABIlizationofactinfilaments.PhosphorylatesLIMK1,akinasethatalsoinhibitstheactivityofcofilin.Phosphorylatesintegrinbeta5/ITGB5andthusregulatescellmotility.PhosphorylatesARHGEF2andactivatesthedownstreamtargetRHOAthatplaysaroleintheregulationofassemblyoffocaladhesionsandactinstressfibers.StimulatescellsurvivalbyphosphorylatingtheBCL2antagoNISTofcelldeathBAD.Alternatively,inhibitsapoptosisbypreventingcaspase-8bindingtodeathdomainreceptorsinakinaseindependentmanner.Playsaroleincell-cycleprogressionbycontrollinglevelsofthecell-cycleregulatoryproteinCDKN1AandbyphosphorylatingRAN.

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Biotin

Properties:

BindstetramericavidinproteinsincludingStreptavidinandneuravidinwithveryhighaffinity
Molarmass:244.31g/mol
Formula:C₁₀H₁₆N₂O₃S
Applications:Westernblot,immunohistochemistry,andELISA

BiotinDatasheet

品牌介绍

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。

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