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当前位置: 首页 > 产品中心 > Other_buffers > STRESTMARQ/抗PAK4抗体(pSer474)/SPC-1044D-APC/100-µl
商品详细STRESTMARQ/抗PAK4抗体(pSer474)/SPC-1044D-APC/100-µl
STRESTMARQ/抗PAK4抗体(pSer474)/SPC-1044D-APC/100-µl
STRESTMARQ/抗PAK4抗体(pSer474)/SPC-1044D-APC/100-µl
商品编号: SPC-1044D-APC
市场价: ¥6820.00
美元价: 4092.00
产地: 美国(厂家直采)
公司:
产品分类: 其它缓冲液
公司分类: Other_buffers
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNamePAK4Antibody(pSer474)
Description

RabbitAnti-HumanPAK4(pSer474)Polyclonal

SpeciesReactivityHuman
ApplicationsWB,AM
AntibodyDilutionWB(1:250);optimaldilutionsforassaysshouldbedeterminedbytheuser.
HostSpeciesRabbit
ImmunogenSpeciesHuman
ImmunogenAphospho-specificpeptidecorrespondingtoresiduessurroundingSer474ofhumanPAK4(AA471-477)
ConjugatesAlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBufferPBSpH7.4,50%glycerol,0.025%Thimerosal
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationPeptideAffinityPurified
ClonalityPolyclonal
SpecificityDetects64.072kDa.
CiteThisProductStressMarqBiosciencesCat#SPC-1044,RRID:AB_2709191
CertificateofAnalysisA1:250dilutionofSPC-1044wassufficientfordetectionofPAK4(pSer474)in10µgofHeLacelllysatebyECLimmunoblotanalysisusinggoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNamesPAK4Antibody,PAK-4Antibody,Pak4Antibody,PAK4_HUMANAntibody,ProteinkinaserelatedtoS.cerevisiaeSTE20effectorforCdc42HsAntibody,SerinethreoninekinasePAK4Antibody,Serine/threonineproteinkinasePAK4Antibody,Serine/threonineproteinkinasePAK4Antibody,Serine/threonine-proteinkinasePAK4Antibody,KIAA1142Antibody,p21activatedkinase4Antibody,p21Cdc42/Rac1-actiatedkinase4Antibody,P21protein(Cdc42/Rac)activatedkinase4Antibody,p21(CDKN1A)activatedkinase4Antibody,p21-activatedkinase4Antibody
CellularLocalizationCytoplasm
AccessionNumberNP_005875
GeneID10298
SwissProtO96013
ScientificBackgroundSerine/threonineproteinkinasethatplaysaroleinavarietyofdifferentsignalingpathwaysincludingCytoskeletonregulation,cellmigration,growth,proliferationorcellsurvival.ActivationbyvariouseffectorsincludinggrowthfactorreceptorsoractiveCDC42andRAC1resultsinaconformationalchangeandasubsequentautophosphorylationonseveralserineand/orthreonineresidues.PhosphorylatesandinactivatestheproteinphosphataseSSH1,leADIngtoincreasedinhibitoryphosphorylationoftheactinbinding/depolymerizingfactorcofilin.DecreasedcofilinactivitymayleadtostABIlizationofactinfilaments.PhosphorylatesLIMK1,akinasethatalsoinhibitstheactivityofcofilin.Phosphorylatesintegrinbeta5/ITGB5andthusregulatescellmotility.PhosphorylatesARHGEF2andactivatesthedownstreamtargetRHOAthatplaysaroleintheregulationofassemblyoffocaladhesionsandactinstressfibers.StimulatescellsurvivalbyphosphorylatingtheBCL2antagoNISTofcelldeathBAD.Alternatively,inhibitsapoptosisbypreventingcaspase-8bindingtodeathdomainreceptorsinakinaseindependentmanner.Playsaroleincell-cycleprogressionbycontrollinglevelsofthecell-cycleregulatoryproteinCDKN1AandbyphosphorylatingRAN.

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APC(Allophycocyanin)
Overview:
  • Highquantumyield
  • Largephycobiliprotein
  • 6chromophorespermolecule
  • Isolatedfromredalgae
  • MolecularWeight:105kDa

APCDatasheet

 APC Fluorophore Absorption and Emission SpectrumOpticalProperties:

λex =650nm

λem=660nm

εmax=7.0×105

Φf= 0.68

Brightness= 476

Laser =594or633 nm

Filterset =Cy®5

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。