StressMarq/Anti-p27 Kip1 Antibody/SPC-1282D-BI/100-µl-免疫在线蚂蚁淘旗下平台

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商品详细StressMarq/Anti-p27 Kip1 Antibody/SPC-1282D-BI/100-µl

StressMarq/Anti-p27 Kip1 Antibody/SPC-1282D-BI/100-µl

商品编号： SPC-1282D-BI

品牌： StressMarq Biosciences

市场价： ¥5960.00

美元价： 3576.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Overview:

Product Name p27 Kip1 Antibody

Description

Rabbit Anti-Human p27 Kip1 Polyclonal

Species Reactivity Human

Applications IHC, ELISA

Antibody Dilution IHC (1:100), ELISA (1:40000); optimal dilutions for assays should be determined by the user.

Host Species Rabbit

Immunogen Species Human

Immunogen Synthesized peptide derived from Internal of human p27 Kip1.

Conjugates

Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer	PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Storage Temperature	-20ºC
Shipping Temperature	Blue Ice or 4ºC
Purification	Affinity Purified
Clonality	Polyclonal
Isotype	IgG
Specificity	Detects endogenous levels of total p27 Kip1 protein.
Cite This Product	StressMarq Biosciences Cat# SPC-1282, RRID: AB_2712881
Certificate of Analysis	A 1:100 dilution of SPC-1282 was sufficient for detection of p27 Kip1 in human brain tissue using Goat Anti-Rabbit IgG as the secondary antibody.

Biological Description

Alternative Names	Cdki1b Antibody, CDKN 1B Antibody, CDKN 4 Antibody, Cyclin Dependent Kinase Inhibitor 1B Antibody, Cyclin dependent kinase inhibitor p27 Antibody, Cyclin-dependent kinase inhibitor p27 Kip1 Antibody, KIP 1 Antibody, MEN1B Antibody, MEN4 Antibody, p27 Antibody, p27 Kip1 Antibody
Research Areas	Cancer, Cell Cycle, Cip/Kip
Cellular Localization	Cytoplasm, Endosome, Nucleus
Accession Number	NP_004055.1
Gene ID	1027
Swiss Prot	P46527
Scientific Background	The cyclin-dependent kinase inhibitor, p27 Kip1 is a tumor suppressor protein that acts in the nucleus to enforce cell cycle checkpoints. Like its relatives, p57 Kip2 and p21 Waf1/Cip1, the ability to enforce the G1 restriction point is derived from its inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes. Expression levels of p27 are upregulated in quiescent cells and in cells treated with cAMP or other negative cell cycle regulators. Downregulation of p27 can be induced by treatment with interleukin-2 or other mitogens; this involves phosphorylation of p27 and its degradation by the ubiquitin-proteasome pathway (1-4).
References	1. Lloyd, R.V. et al. (1999) Am J Pathol 154, 313-23. 2. Polyak, K. et al. (1994) Genes Dev 8, 9-22. 3. Kato, J.Y. et al. (1994) Cell 79, 487-96. 4. Vlach, J. et al. (1997) EMBO J 16, 5334-44.

Product Images

<p>Immunohistochemistry analysis using Rabbit Anti-p27 Kip1 Polyclonal Antibody (SPC-1282). Tissue: Brain tissue. Species: Human. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-p27 Kip1 Polyclonal Antibody (SPC-1282) at 1:100. The image on the right is treated with the synthesized peptide.</p>

Immunohistochemistry analysis using Rabbit Anti-p27 Kip1 Polyclonal Antibody (SPC-1282). Tissue: Brain tissue. Species: Human. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-p27 Kip1 Polyclonal Antibody (SPC-1282) at 1:100. The image on the right is treated with the synthesized peptide.

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Biotin

Properties:

Binds tetrameric avidin proteins including Streptavidin and neuravidin with very high affinity
Molar mass: 244.31 g/mol
Formula: C₁₀H₁₆N₂O₃S
Applications: Western blot, immunohistochemistry, and ELISA

Biotin Datasheet

品牌介绍

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。

公司介绍