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当前位置： 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-p27 Kip1 Antibody/SPC-1282D-A488/100-µl
商品详细StressMarq/Anti-p27 Kip1 Antibody/SPC-1282D-A488/100-µl
StressMarq/Anti-p27 Kip1 Antibody/SPC-1282D-A488/100-µl
StressMarq/Anti-p27 Kip1 Antibody/SPC-1282D-A488/100-µl
商品编号： SPC-1282D-A488
市场价： ¥6040.00
美元价： 3624.00
产地： 美国(厂家直采)
公司：
产品分类： 酸碱缓冲液
公司分类： acid_base_buffer_solution
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

Product Name p27 Kip1 Antibody
Description

Rabbit Anti-Human p27 Kip1 Polyclonal

Species Reactivity Human
Applications IHC, ELISA
Antibody Dilution IHC (1:100), ELISA (1:40000); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen Synthesized peptide derived from Internal of human p27 Kip1.
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Affinity Purified
Clonality Polyclonal
Isotype IgG
Specificity Detects endogenous levels of total p27 Kip1 protein.
Cite This Product StressMarq Biosciences Cat# SPC-1282, RRID: AB_2712881
Certificate of Analysis A 1:100 dilution of SPC-1282 was sufficient for detection of p27 Kip1 in human brain tissue using Goat Anti-Rabbit IgG as the secondary antibody.

Biological Description

Alternative Names Cdki1b Antibody, CDKN 1B Antibody, CDKN 4 Antibody, Cyclin Dependent Kinase Inhibitor 1B Antibody, Cyclin dependent kinase inhibitor p27 Antibody, Cyclin-dependent kinase inhibitor p27 Kip1 Antibody, KIP 1 Antibody, MEN1B Antibody, MEN4 Antibody, p27 Antibody, p27 Kip1 Antibody
Research Areas Cancer, Cell Cycle, Cip/Kip
Cellular Localization Cytoplasm, Endosome, Nucleus
Accession Number NP_004055.1
Gene ID 1027
Swiss Prot P46527
Scientific Background The cyclin-dependent kinase inhibitor, p27 Kip1 is a tumor suppressor protein that acts in the nucleus to enforce cell cycle checkpoints. Like its relatives, p57 Kip2 and p21 Waf1/Cip1, the ability to enforce the G1 restriction point is derived from its inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes. Expression levels of p27 are upregulated in quiescent cells and in cells treated with cAMP or other negative cell cycle regulators. Downregulation of p27 can be induced by treatment with interleukin-2 or other mitogens; this involves phosphorylation of p27 and its degradation by the ubiquitin-proteasome pathway (1-4).
References 1. Lloyd, R.V. et al. (1999) Am J Pathol 154, 313-23.
2. Polyak, K. et al. (1994) Genes Dev 8, 9-22.
3. Kato, J.Y. et al. (1994) Cell 79, 487-96.
4. Vlach, J. et al. (1997) EMBO J 16, 5334-44.

Product Images

<p>Immunohistochemistry analysis using Rabbit Anti-p27 Kip1 Polyclonal Antibody (SPC-1282). Tissue: Brain tissue. Species: Human. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-p27 Kip1 Polyclonal Antibody (SPC-1282) at 1:100. The image on the right is treated with the synthesized peptide.</p>

Immunohistochemistry analysis using Rabbit Anti-p27 Kip1 Polyclonal Antibody (SPC-1282). Tissue: Brain tissue. Species: Human. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-p27 Kip1 Polyclonal Antibody (SPC-1282) at 1:100. The image on the right is treated with the synthesized peptide.

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  ATTO 488
Overview:

  • High fluorescence yield
  • High photostability
  • Very hydrophilic
  • Excellent solubility in water
  • Very little aggregation
  • New dye with net charge of -1
  • Molar Mass: 804 g/mol 

ATTO 488 Datasheet

  ATTO 488 Fluorophore Excitation and Emission SpectraOptical Properties:

λex = 501 nm

λem = 523 nm

εmax = 9.0×104

Φf = 0.80

τfl = 4.1 ns

Brightness = 72

Laser = 488 nm

Filter set = FITC

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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