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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/p23 Protein/SPR-303B/100-µg
商品详细StressMarq/p23 Protein/SPR-303B/100-µg
StressMarq/p23 Protein/SPR-303B/100-µg
StressMarq/p23 Protein/SPR-303B/100-µg
商品编号: SPR-303B
市场价: ¥6380.00
美元价: 3828.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNamep23Protein
Description

HumanRecombinantp23Protein

ApplicationsWB,SDS-PAGE,FunctionalAssay
ConcentrationLot/batchspecific.Seeincludeddatasheet.
ConjugatesNotag

Properties

StorageBuffer20mMHEPESbufferpH7.2,80mMNaCl,10%glycerol
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationAffinityPurified
Specificity~23kDa
CiteThisProductHumanRecombinantp23Protein(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SPR-303)
CertificateofAnalysisThisproducthasbeencertified>90%pureusingSDSPAGEanalysis.4uMSPR-303,whenaddedto2uMSPR-300(Aha1)-activatedHSP90(2uM;His-taggedHSP90beta)in33mMHepespH7.2,30mMNaCl,5mMMgCl2,1mMDTT,1.5mMATPina100ulreactionat37degreesC,eliminatedallAha1-mediatedATPasestimulationaswellasintrinsicHSP90ATPaseactivity.(Thisisanenzyme-linkedATPregenerationassaytrackinglossofNADHabsorbanceat340nm).

BIOLOGicalDescription

AlternativeNamesSid3177Protein,Cochaperonep23Protein,cPGESProtein,HSP90cochaperoneProtein,cytosolicprostaglandinE2synthaseProtein,PTGES3Protein,TEBPProtein,ProstaglandinEsynthase3protein
ResearchAreasCancer,HeatShock
CellularLocalizationCytoplasm
AccessionNumberNP_006592.3
GeneID10728
SwissProtQ15185
ScientificBackgroundp23isahighlyconservedubiquitousprotein,knowntohaveanimportantfunctionasacochaperonefortheHSP90chaperoningsystem(1).Studieshaverevealedthatp23isasmallprotein(18to25kDa)withasimplestructure(2,3).p23doesnothaveanystructuralhomologywithanyotherknownproteins(1).p23wasfirstdiscoveredasapartoftheHSP90-progesteronereceptorcomplexalongwithHSP70,p54andp50(1).p23isaphosphor-protein,whichishighlyacidicandhasanasparticacid-richc-terminaldomain(1).Numerousstudieshavefoundp23tobeassociatedwithotherclientproteinslikeFestyrosinekinase(4),thehemeregulatedkinaseHRI(5),hsf1transcriptionfactor(4),arylhydrocarbonreceptor(4),telomerase(6),andHepadnavirusreversetranscriptase(7).Inspiteofseveralyearsofstudy,theexactfunctionalsignificanceofp23isstillnotclear(8).p23isthoughttobeinvolvedintheadenosinetriphosphate–mediatedHSP90bindingofclientproteins(8).SincemanyHSP90clientproteinsareinvolvedinoncogenicsurvivalsignaling,arecentstudyhasconcludedp23tobeapromisingtargetinleukemicapoptosis(9).HSP90anditsco-chaperonep23arecertainlyamongtheemerginganti-tumortargetsinoncology.
References1.JohnsonJ.L.,BeitoT.G.,KrcoC.J.&ToftD.O.(1994)MolCellBiol.14:1956-63.
2.WeiklT.,AbelmannK.&BuchnerJ.(1999)JMolBiol.293:685-91.
3.WeaverA.J.,SullivanW.P.,FeltsS.J.,OwenB.A.&Toft,D.O.(2000)JBiolChem.275:23045-52.
4.NairS.C.,etal.(1996)CellStressChaperones.1:237-50.
5.XuZ.,etal.(1997)EurJBiochem.246,461-70.
6.HoltS.E.,etal.(1999)GenesDev.13:817-26.
7.HuJ.,ToftD.,AnselmoD.&WangX.(2002)JVirol.76:269-79.
8.FeltsS.J.&ToftD.O.(2003)CellStressChaperones.8:108-13.
9.GausdalG.,GjertsenB.T.,FladmarkK.E.,DemolH.,VandekerckhoveJ.&DoskelandS.O.(2004)Leukemia.

ProductImages

<p>SDS-PAGE of native human 23kDa p23 protein (SPR-303).</p>

SDS-PAGEofnativehuman23kDap23protein(SPR-303).

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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。