StressMarq/Nilotinib/SIH-463-25MG/25-mg
商品编号：
SIH-463-25MG
市场价：
¥5000.00
美元价：
3000.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| Product Name | Nilotinib |
| Description | BCR-ABL kinase inhibitor |
| Purity | >99% |
| CAS No. | 641571-10-0 |
| Molecular Formula | C28H22F3N7O |
| Molecular Weight | 529.5 |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (50 mg/ml), chloroform, DMF (~3 mg/ml), water(very poorly soluble, maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility), and ethanol(very poorly soluble) |
| Source | Synthetic |
| Appearance | Crystalline powder |
| SMILES | C5=C([N]1C=C(N=C1)C)C=C(NC(=O)C2=CC(=C(C=C2)C)NC3=NC(=CC=N3)C4=CN=CC=C4)C=C5C(F)(F)F |
| InChI | InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h4-16H,1-2H3,(H,35,39)(H,33,36,37) |
| InChIKey | HHZIURLSWUIHRB-UHFFFAOYSA-N |
| Safety Phrases | Classification: Not a hazardous substance or mixture.Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Nilotinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-463) |
Biological Description
| Alternative Names | 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide |
| Research Areas | Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 644241 |
| Scientific Background | Nilotinib is a potent and selective Bcr/Abl tyrosine kinase inhibitor, as well as, an inhibitor of JAK2/STAT5, and MDM2 at the post-translational level. Nilotinib shows antiproliferative and antitumor effects in vivo. |
| References |
1. Gallipoli P., et al. (2014) Blood. 2. Zhang H., Gu L., Liu T., Chiang K.Y., & Zhou M. (2014) PloS One. 9(6): e100960. |
Product Images
Chemical structure of Nilotinib (SIH-463), a BCR-ABL kinase inhibitor. CAS #: 641571-10-0. Molecular Formula: C28H22F3N7O. Molecular Weight: 529.5 g/mol.
Product Citations (0)
Currently there are no citations for this product.
品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
