StressMarq/Nilotinib/SIH-463-5MG/5-mg
商品编号：
SIH-463-5MG
市场价：
¥1300.00
美元价：
780.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Nilotinib |
| Description | BCR-ABLkinaseinhibitor |
| Purity | >99% |
| CASNo. | 641571-10-0 |
| MolecularFormula | C28H22F3N7O |
| MolecularWeight | 529.5 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO(50mg/ml),chloroform,DMF(~3mg/ml),water(verypoorlysoluble,maximumsolubilityinplainwaterisestimatedtobeabout10-20µM;buffers,serum,orotheradditivesmayincreaseordecreasetheaqueoussolubility),andethanol(verypoorlysoluble) |
| Source | Synthetic |
| Appearance | Crystallinepowder |
| SMILES | C5=C([N]1C=C(N=C1)C)C=C(NC(=O)C2=CC(=C(C=C2)C)NC3=NC(=CC=N3)C4=CN=CC=C4)C=C5C(F)(F)F |
| InChI | InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h4-16H,1-2H3,(H,35,39)(H,33,36,37) |
| InChIKey | HHZIURLSWUIHRB-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Notahazardoussubstanceormixture.SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection. |
| CiteThisProduct | Nilotinib(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-463) |
BIOLOGicalDescription
| AlternativeNames | 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide |
| ResearchAreas | Cancer,Apoptosis,CancerGrowthInhibitors,CellSignaling,TyrosineKinaseInhibitors |
| PubChemID | 644241 |
| ScientificBackground | NilotinibisapotentandselectiveBcr/Abltyrosinekinaseinhibitor,aswellas,aninhibitorofJAK2/STAT5,andMDM2atthepost-translationallevel.Nilotinibshowsantiproliferativeandantitumoreffectsinvivo. |
| References | 1.GallipoliP.,etal.(2014)Blood. 2.ZhangH.,GuL.,LiuT.,ChiangK.Y.,&ZhouM.(2014)PloSOne.9(6):e100960. |
ProductImages
ChemicalstructureofNilotinib(SIH-463),aBCR-ABLkinaseinhibitor.CAS#:641571-10-0.MolecularFormula:C28H22F3N7O.MolecularWeight:529.5g/mol.
ProductCitations(0)
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
