StressMarq/Niclosamide/SIH-406-1G/1-g
商品编号：
SIH-406-1G
市场价：
¥780.00
美元价：
468.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Niclosamide |
| Description | Autophagyinducer |
| Purity | >98%(TLC);NMR(Conforms) |
| CASNo. | 50-65-7 |
| MolecularFormula | C13H8Cl2N2O4 |
| MolecularWeight | 327.12 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inducer |
| Solubility | Solubleto25mMinethanolandto10mMinDMSO |
| Source | Synthetic |
| Appearance | Paleyellowsolid |
| SMILES | C2=C(C(NC1=C(C=C([N+](=O)[O-])C=C1)Cl)=O)C(=CC=C2Cl)O |
| InChI | InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19) |
| InChIKey | RJMUSRYZPJIFPJ-UHFFFAOYSA-N |
| SafetyPhrases | Classification:NotWHMIScontrolled.SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection. |
| CiteThisProduct | Niclosamide(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-406) |
BIOLOGicalDescription
| AlternativeNames | 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide |
| ResearchAreas | Cancer,Autophagy |
| PubChemID | 4477 |
| ScientificBackground | Niclosamideispartoftheanthelminticsdrugclass,whichareusedtotreattapeworminfectionsinhumans.NiclosamidehasbeenshowntoselectivelyinhibittheStat-3signallingpathway,specificallybyinhibitingitsactivation,nucleartranslocationandtranscriptionalactivity.IthasalsobeenreportedthatNiclosamideinhibitsmTORC1,therebyinducingautophagyandincreasingtheformationofautophagosomes. |
| References | 1.PanJ.X.,etal.(2012)ChinJCancer.31(4):178-84. |
ProductImages
ChemicalstructureofNiclosamide(SIH-406),aAutophagyinducer.CAS#:50-65-7.MolecularFormula:C13H8Cl2N2O4.MolecularWeight:327.12g/mol.
ProductCitations(0)
Currentlytherearenocitationsforthisproduct.
品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
