StressMarq/Necrostatin/SIH-213-10MG/10-mg
商品编号：
SIH-213-10MG
市场价：
¥1340.00
美元价：
804.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Necrostatin |
| Description | Necroptosisinhibitor |
| Purity | >98% |
| CASNo. | 4311-88-0 |
| MolecularFormula | C13H13N3OS |
| MolecularWeight | 259.33 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | Solubleto15mMinethanol,andto30mMinDMSO |
| Source | Synthetic |
| Appearance | LightYellowSolid |
| SMILES | CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32 |
| InChI | InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18) |
| InChIKey | TXUWMXQFNYDOEZ-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection |
| CiteThisProduct | Necrostatin(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-213) |
BIOLOGicalDescription
| AlternativeNames | 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone,Necrostatin-1 |
| ResearchAreas | Cancer,Apoptosis |
| PubChemID | 2828334 |
| ScientificBackground | Necrostatin-1isaspecificinhibitorofnecroptosisthatreducesischemictissuedamageinstrokemodels(1).IthasalsobeenrecentlyconfirmedtobeanallostericRIP1kinaseinhibitor,preotectiveinNMDa-mediatedexcitotoxicityandacutepathologies(2,3). |
| References | 1.YouZ.,etal.(2008)JCerebBloodFlowMetab.28(9):1564-1573. 2.VandenabeeleP.,etal.(2010)NatRevMolCellBiol.11:700-714. 3.DegterevA.,etal.(2008)NatChemBiol.4:313-321. |
ProductImages
ChemicalstructureofNecrostatin(SIH-213),aInhibitsnecroptosis.CAS#:4311-88-0.MolecularFormula:C13H13N3OS.MolecularWeight:259.33g/mol.
ProductCitations(2)
OtherCitations
Deathreceptor3mediatesnecroptoticcelldeath.
Bittner,S.Knoll,G.andEhrenschwender,M.(2016)CellMolLifeSci.74(3):543-554.
PubMedID:27592300Applications:Invitroinhibition
BortezomibsensitisesTRAIL-resistantHPV-positiveheadandneckcancercellstoTRAILthroughacaspase-dependent,E6-independentmechanism.
Bullenkamp,J.etal.(2014)CellDeathDis.5:e1489.
PubMedID:25341043Applications:CellviABIlityassay
品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
