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当前位置： 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Anti-mTOR Antibody (pSer2448)/SPC-1034D-A488/100-µl
商品详细StressMarq/Anti-mTOR Antibody (pSer2448)/SPC-1034D-A488/100-µl
StressMarq/Anti-mTOR Antibody (pSer2448)/SPC-1034D-A488/100-µl
StressMarq/Anti-mTOR Antibody (pSer2448)/SPC-1034D-A488/100-µl
商品编号： SPC-1034D-A488
市场价： ¥6840.00
美元价： 4104.00
产地： 美国(厂家直采)
公司：
产品分类： 酸碱缓冲液
公司分类： acid_base_buffer_solution
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

Product Name mTOR Antibody (pSer2448)
Description

Rabbit Anti-Human mTOR (pSer2448) Polyclonal

Species Reactivity Human
Applications WB, AM
Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen A phospho-specific peptide corresponding to residues surrounding Ser2448 of human mTOR (AA2445-2451)
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Peptide Affinity Purified
Clonality Polyclonal
Specificity Detects 288.892 kDa.
Cite This Product StressMarq Biosciences Cat# SPC-1034, RRID: AB_2709011
Certificate of Analysis A 1:250 dilution of SPC-1034 was sufficient for detection of mTOR (pSer2448) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names FK506 binding protein 12 rapamycin associated protein 1 antibody, FK506 binding protein 12 rapamycin associated protein 2 antibody, FKBP rapamycin associated protein antibody, FKBP12 rapamycin complex associated protein antibody, FRAP antibody, FRAP1 antibody, FRAP2 antibody, Mammalian target of rapamycin antibody, Mechanistic target of rapamycin antibody, mTOR antibody, MTOR_HUMAN antibody, RAFT1 antibody, Rapamycin and FKBP12 target 1 antibody, Rapamycin target protein 1 antibody, Rapamycin target protein antibody, RAPT1 antibody, Serine/threonine-protein kinase mTOR antibody
Cellular Localization Cytoplasm, Endoplasmic reticulum membrane, Golgi Apparatus Membrane, Lysosome
Accession Number NP_004949
Gene ID 2475
Swiss Prot P42345
Scientific Background MTOR is a protein-serine/threonine kinase. It regulates various cellular pathways such as insulin signalling, eIF4e and p70S6 kinase activation for protein synthesis, HIFa, VEGF, cell proliferation, nutrient and hormone signals, ribosome biogenesis, regulation of cell cycle progrssion, angiogensis, cell polarity and cytokeleton reorganization. Dysregulation in signalling that leads to constant activation of mTOR lead to uncontrolled prolifertaion and cell cycle progression and oncogensis. Increased invasiveness has also be shown do be associated with mTOR activity. While it features a wide range of mutations, this might reflect the very large size of the protein rather than its identification as a tumour suppressor protein.

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  ATTO 488
Overview:

  • High fluorescence yield
  • High photostability
  • Very hydrophilic
  • Excellent solubility in water
  • Very little aggregation
  • New dye with net charge of -1
  • Molar Mass: 804 g/mol 

ATTO 488 Datasheet

  ATTO 488 Fluorophore Excitation and Emission SpectraOptical Properties:

λex = 501 nm

λem = 523 nm

εmax = 9.0×104

Φf = 0.80

τfl = 4.1 ns

Brightness = 72

Laser = 488 nm

Filter set = FITC

 

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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