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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > StressMarq/Mn SOD Protein/SPR-130A/50-µg
商品详细StressMarq/Mn SOD Protein/SPR-130A/50-µg
StressMarq/Mn SOD Protein/SPR-130A/50-µg
StressMarq/Mn SOD Protein/SPR-130A/50-µg
商品编号: SPR-130A
市场价: ¥8340.00
美元价: 5004.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

ProductNameMnSODProtein
Description

RatRecombinantMnSODProtein

ApplicationsWB,SDS-PAGE
ConcentrationLot/batchspecific.Seeincludeddatasheet.
ConjugatesHistag

Properties

StorageBuffer50mMTris/HClpH7.7,0.3MNaCl
StorageTemperature-20ºC
ShippingTemperatureBlueIceor4ºC
PurificationAffinityPurified
Specificity~25kDa
CiteThisProductRatRecombinantMnSODProtein(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SPR-130)
CertificateofAnalysisThisproducthasbeencertified>90%pureusingSDS-PAGEanalysis.
OtherRelevantInformationNoleadersequence

BIOLOGicalDescription

AlternativeNamesManganeseSODProtein,IPOBProtein,MnSODProtein,SOD2Protein,SuperoxideDismutase(Mn)mitochondrialprotein
ResearchAreasCancer,CellSignaling,Chaperones,OxidativeStress,Trafficking
CellularLocalizationMitochondrionMatrix
AccessionNumberBC070913
GeneID24787
SwissProtP07895
ScientificBackgroundSuperoxidedismutase(SOD)isanendogenouslyproducedintracellularenzymepresentinalmosteverycellinthebody(3).ItworksbycatalyzingthedismutationofthesuperoxiderADIcalO2ˉtoO2andH2O2,whicharethenmetabolizedtoH2OandO2bycatalaseandglutathioneperoxidase(2,5).Ingeneral,SODsplayamajorroleinantioxidantdefensemechanisms(4).TherearetwomaintypesofSODinmammaliancells.Oneform(SOD1)containsCuandZnionsasahomodimerandexistsinthecytoplasm.Thetwosubunitsof16kDaeacharelinkedbytwocysteinesforminganintra-subunitdisulphidebridge(3).Thesecondform(SOD2)isamanganesecontainingenzymeandresidesinthemitochondrialmatrix.Itisahomotetramerof80kDa.Thethirdform(SOD3orEC-SOD)islikeSOD1inthatitcontainsCuandZnions,howeveritisdistinctinthatitisahomotetramer,withamassof30kDAanditexistsonlyintheextracellularspace(8).SOD3canalsobedistinguishedbyitsheparin-bindingcapacity(1).
References1.AdachiT.,etal.(1992)Clin.Chim.Acta.212:89-102.
2.BarristerJ.V.,etal.(1987)Crit.Rev.Biochem.22:111-180.
3.FurukawaY.,andO’HalloranT.(2006)Antioxidants&RedoSignaling.8(No5):6.
4.GaoB.,etal.(2003).AmJPhysiolLungCellMolPhysiol.284:L917-L925.
5.HassanH.M.(1988).FreeRadicalBiol.Med.5:377-385.
6.KurobeN.,etal.(1990)ClinicaChimicaActa.192:171-180.
7.OjikaT.,etal.(1991)ActaHistochemCytochem.24(50):489-495.
8.WispeJ.R.,etal.(1989)BBA.994:30-36.

ProductImages

<p>SDS-PAGE of 25kDa rat Mn SOD (SPR-130).</p>

SDS-PAGEof25kDaratMnSOD(SPR-130).

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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。