应力MARQ/MLN4924/SIH-331-1MG/1-mg
商品编号：
SIH-331-1MG
市场价：
¥16780.00
美元价：
10068.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | MLN4924 |
| Description | NEDD8activatingenzymeinhibitor |
| Purity | >98% |
| CASNo. | 905579-51-3 |
| MolecularFormula | C21H25N5O4S |
| MolecularWeight | 443.2 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | Solublein10mg/mlDMSO |
| Source | Synthetic |
| Appearance | WhitePowder |
| SMILES | C1CC2=CC=CC=C2[[email protected]]1NC3=C4C=CN(C4=NC=N3)[[email protected]@H]5C[[email protected]]([[email protected]](C5)O)COS(=O)(=O)N |
| InChI | InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-, |
| InChIKey | MPUQHZXIXSTTDU-QXGSTGNESA-N |
| SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionS24/25-Avoidcontactwithskinandeyes |
| CiteThisProduct | mlN4924(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-331) |
BIOLOGicalDescription
| AlternativeNames | [(1S,2S,4R)-4-{4-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methylsulfamate,Sulfamicacid |
| ResearchAreas | Cancer,Apoptosis |
| PubChemID | 16720766 |
| ScientificBackground | PotentandselectiveNEDD8-activatingenzyme(NAE)inhibitor.Itdisruptscullin-RINGligase-mediatedproteinturnoverleADIngtoapoptosisinhumantumorcells.Itsuppressesthegrowthofhumantumorxenograftsinmice.Cellpermeable. |
| References | 1.SoucyT.A.,etal.(2009)Nature.458:732. 2.MilhollenM.A.,etal.(2010)Blood.116:1515. |
ProductImages
ChemicalstructureofMLN4924(SIH-331),aNedd8activatingenzymeinhibitor.CAS#:905579-51-3.MolecularFormula:C21H25N5O4S.MolecularWeight:443.2g/mol.
ProductCitations(0)
Currentlytherearenocitationsforthisproduct.
品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
