StressMarq/Anti-MELK Antibody/SPC-1166D-A488/100-µl-免疫在线蚂蚁淘旗下平台

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商品详细StressMarq/Anti-MELK Antibody/SPC-1166D-A488/100-µl

StressMarq/Anti-MELK Antibody/SPC-1166D-A488/100-µl

商品编号： SPC-1166D-A488

品牌： StressMarq Biosciences

市场价： ¥6840.00

美元价： 4104.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Overview:

ProductName MELKAntibody

Description

RabbitAnti-HumanMELKPolyclonal

SpeciesReactivity Human,Mouse

Applications WB,AM

AntibodyDilution WB(1:250);optimaldilutionsforassaysshouldbedeterminedbytheuser.

HostSpecies Rabbit

ImmunogenSpecies Human

Immunogen SyntheticpeptideofhumanMELK(AA249-263)

Conjugates

AlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBuffer	PBSpH7.4,50%glycerol,0.025%Thimerosal
StorageTemperature	-20ºC
ShippingTemperature	BlueIceor4ºC
Purification	PeptideAffinityPurified
Clonality	Polyclonal
Specificity	Detects~75kDa.
CiteThisProduct	StressMarqBiosciencesCat#SPC-1166,RRID:AB_2711387
CertificateofAnalysis	A1:250dilutionofSPC-1166wassufficientfordetectionofMELKin10µgofHeLacelllysatebyECLimmunoblotanalysisusinggoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNames	hMELKantibody,HPK38antibody,hPK38antibody,Maternalembryonicleucinezipperkinaseantibody,MELKantibody,MELK_HUMANantibody,MPK38antibody,pEg3kinaseantibody,ProteinkinaseEg3antibody,ProteinkinasePK38antibody,TyrosineproteinkinaseMELKantibody
CellularLocalization	Cytoplasm
AccessionNumber	NP_055606
GeneID	9833
SwissProt	Q14680
ScientificBackground	MELKisaprotein-serine/threoninekinaseintheCAMKSer/Thrproteinkinasefamily,SNF1subfamily.Itisinvolvedinvariousprocessessuchascellcycleregulation,self-renewalofstemcells,apoptosisandsplicingregulation.ItexhibitsabroadsubstratespecificitywithtargetsthatincludeBCL2L14,CDC25B,MAP3K5/ASK1andZNF622.ItisanactivatorofapoptosisbyphosphorylatingandactivatingMAP3K5/ASK1ItsphosphorylationofCDC25B,promotinglocalizationofCDC25Btothecentrosomeandthespindlepolesduringmitosis.ItisrequiredforproliferationofembryonicandpostnatalmultipotentneuralProgenitors.PhosphorylatesandinhibitsBCL2L14,possIBLyleADIngtoaffectmammarycarcinogenesisbymediatinginhibitionofthepro-apoptoticfunctionofBCL2L14.ItinhibitsspliceosomeassemblyduringmitosisbyphosphorylatingZNF622,whichcontributestoitsredirectiontothenucleus.ItinteractswithZNF622andPPP1R8.ItisactivatedbyautophosphorylationoftheT-loopatThr-167andSer-171:incontrasttoothermembersoftheSNF1subfamily,phosphorylationatThr-167isnotmediatedbySTK11/LKB1butviaautophosphorylationinstead.Itisup-regulatedinmanycancerscells.Itisexpressedinplacenta,kidney,thymus,testis,ovaryandintestine,andisup-regulatedinmanycancerscells.Itcanoccurin8humanisoformsrangingfrom74.642to52.528kDainsize.

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ATTO488

Overview:

Highfluorescenceyield
HighphotostABIlity
Veryhydrophilic
Excellentsolubilityinwater
Verylittleaggregation
Newdyewithnetchargeof-1
MolarMass:804g/mol

ATTO488Datasheet

ATTO 488 Fluorophore Excitation and Emission Spectra

OpticalProperties:

λ_ex =501nm

λ_em=523nm

ε_max=9.0×10⁴

Φ_f= 0.80

τ_fl =4.1ns

Brightness= 72

Laser = 488 nm

Filterset = FITC

品牌介绍

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。

公司介绍