StressMarq/Anti-MEK6 Antibody/SPC-1174D-P594/100-µl-免疫在线蚂蚁淘旗下平台

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商品详细StressMarq/Anti-MEK6 Antibody/SPC-1174D-P594/100-µl

StressMarq/Anti-MEK6 Antibody/SPC-1174D-P594/100-µl

商品编号： SPC-1174D-P594

品牌： StressMarq Biosciences

市场价： ¥6980.00

美元价： 4188.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Overview:

ProductName MEK6Antibody

Description

RabbitAnti-HumanMEK6Polyclonal

SpeciesReactivity Human,Mouse

Applications WB,AM

AntibodyDilution WB(1:250);optimaldilutionsforassaysshouldbedeterminedbytheuser.

HostSpecies Rabbit

ImmunogenSpecies Human

Immunogen SyntheticpeptideofhumanMEK6(AA299-313)

Conjugates

AlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBuffer	PBSpH7.4,50%glycerol,0.025%Thimerosal
StorageTemperature	-20ºC
ShippingTemperature	BlueIceor4ºC
Purification	PeptideAffinityPurified
Clonality	Polyclonal
Specificity	Detects37.492kDa.
CiteThisProduct	StressMarqBiosciencesCat#SPC-1174,RRID:AB_2711513
CertificateofAnalysis	A1:250dilutionofSPC-1174wassufficientfordetectionofMEK6in10µgofHeLacelllysatebyECLimmunoblotanalysisusinggoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNames	Dualspecificitymitogen-activatedproteinkinasekinase6antibody,MAPkinasekinase6antibody,MAP2K6antibody,MAPK/ERKkinase6antibody,MAPKK6antibody,MAPKK6antibody,MEK6antibody,MEK6antibody,MitogenActivatedProteinKinaseKinase6antibody,MKK6antibody,MKK6antibody,MP2K6_HUMANantibody,PRKMK6antibody,Proteinkinasemitogenactivatedkinase6antibody,SAPKkinase3antibody,SAPKK-3antibody,SAPKK3antibody,SKK3antibody,Stress-activatedproteinkinasekinase3antibody
CellularLocalization	Cytoplasm,Cytoskeleton,Nucleus
AccessionNumber	NP_002749
GeneID	5608
SwissProt	P52564
ScientificBackground	DualspecificityproteinkinasewhichactsasanessentialcomponentoftheMAPkinasesignaltransductionpathway.WithMAP3K3/MKK3,catalyzestheconcomitantphosphorylationofathreonineandatyrosineresidueintheMAPkinasesp38MAPK11,MAPK12,MAPK13andMAPK14andplaysanimportantroleintheregulationofcellularresponsestocytokinesandallkindsofstresses.Especially,MAP2K3/MKK3andMAP2K6/MKK6arebothessentialfortheactivationofMAPK11andMAPK13inducedbyenvironmentalstress,whereasMAP2K6/MKK6isthemajorMAPK11activatorinresponsetoTNF.MAP2K6/MKK6alsophosphorylatesandactivatesPAK6.Thep38MAPkinasesignaltransductionpathwayleadstodirectactivationoftranscriptionfactors.Nucleartargetsofp38MAPkinaseincludethetranscriptionfactorsATF2andELK1.Withinthep38MAPKsignaltransductionpathway,MAP3K6/MKK6mediatesphosphorylationofSTAT4throughMAPK14activation,andisthereforerequiredforSTAT4activationandSTAT4-regulatedgeneexpressioninresponsetoIL-12stimulation.ThepathwayisalsocrucialforIL-6-inducedSOCS3expressionanddown-regulationofIL-6-mediatedgeneinduction;andforIFNG-dependentgenetranscription.HasaroleinosteoclastdifferentiationthroughNF-kappa-BtransactivationbyTNFSF11,andinendochondralossificationandsinceSOX9isanotherlikelydownstreamtargetofthep38MAPKpathway.MAP2K6/MKK6mediatesapoptoticcelldeathinthymocytes.Actsalsoasaregulatorformelanocytesdendricity,throughthemodulationofRhofamilyGTPases.

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PE/ATTO594

PE/ATTO594isatandemconjugate,wherePEisexcitedat535nmandtransfersenergytoATTO594viaFRET(fluorescenceresonanceenergytransfer),whichemitsat627nm.

Overview:

Highfluorescenceyield
HighphotostABIlity
Veryhydrophilic
Excellentsolubilityinwater
Verylittleaggregation

PE/ATTO594Datasheet

PE-ATTO 594 Fluorophore Conjugate Excitation and Emission Spectra

OpticalProperties:

λ_ex =535nm

λ_em =627 nm

Laser = 488to561nm

品牌介绍

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。

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