StressMarq/MAPKII Kinase Inhibitor/SIH-120A/1-mg
商品编号：
SIH-120A
市场价：
¥2040.00
美元价：
1224.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | MAPKIIKinaseInhibitor |
| Description | Hsp25KinaseInhibitor |
| Purity | >95% |
| MolecularFormula | C61H113N21O6 |
| MolecularWeight | 1396.7 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSOorH20 |
| Source | Synthetic |
| Appearance | WhiteSolid |
| SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection |
| CiteThisProduct | MAPKIIKinaseInhibitor(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-120) |
BIOLOGicalDescription
| ResearchAreas | Cancer,HeatShock |
| ScientificBackground | TheMAPK(mitogenactivatedproteinkinase)comprisesafamilyofubiquitouspraline-directed,proteinserine/threoninekinaseswhichsignaltransductionpathwaysthatcontrolintracellulareventsincludingacuteresponsestohormonesandmajordevelopmentalchangesinorganisms(1).Thissuperfamilyconsistsofstressactivatedproteinkinases(SAPKs);extracellularsignal-regulatedkinases(ERKs);andp38kinases,eachofwhichformsaseparatepathway(2).Inparticular,MAPKAP-kinaseII(orotherwiseknownasMK2)isinvolvedininflammation,andisconsideredatargetfortherapeuticinterventionforinflammationandcancer(3).MK2isamemberofthep38MAPKinasepathway,andisactivatedbyavarietyofchemicalstressinducersincludinghydrogenperoxide,heavymetals,anisomycin,sodiumsalicylate,LPS,andbiologicalstresssignalssuchastumornecrosisfactor,interleukin-1,ionizingandUVirrADIation,hyperosmoticstressandchemotherapeuticdrugs(3). |
| References | 1.PearsonG.etal.(2001).EndocrineReviews22(2):153-183. 2.FanY.,etal.(2007)Mol.Cells23(1):30-38. 3.Dengetal.(2003)Cell115:61-70. |
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
