StressMarq/Anti-MAPKAPK2 Antibody (pThr222)/SPC-1014D-RPE/100-µl-免疫在线蚂蚁淘旗下平台

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StressMarq/Anti-MAPKAPK2 Antibody (pThr222)/SPC-1014D-RPE/100-µl

商品编号： SPC-1014D-RPE

品牌： StressMarq Biosciences

市场价： ¥6780.00

美元价： 4068.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Overview:

Product Name MAPKAPK2 Antibody (pThr222)

Description

Rabbit Anti-Human MAPKAPK2 (pThr222) Polyclonal

Species Reactivity Human

Applications WB, AM

Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user.

Host Species Rabbit

Immunogen Species Human

Immunogen A phospho-specific peptide corresponding to residues surrounding Thr222 of human MAPKAPK2 (AA219-226)

Conjugates

Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature	-20ºC
Shipping Temperature	Blue Ice or 4ºC
Purification	Peptide Affinity Purified
Clonality	Polyclonal
Specificity	Detects 45.568 kDa.
Cite This Product	StressMarq Biosciences Cat# SPC-1014, RRID: AB_2708651
Certificate of Analysis	A 1:250 dilution of SPC-1014 was sufficient for detection of MAPKAPK2 (pThr222) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names	MAP kinase activated protein Kinase 2 antibody, MAPK2_HUMAN antibody, MAPKAP K2 antibody, MAPKAP kinase 2 antibody, MAPKAPK2 antibody, Mitogen activated protein kinase activated protein kinase 2 antibody, MK 2 antibody, MK2 antibody
Cellular Localization	Cytoplasmic
Accession Number	NP_116584
Gene ID	9261
Swiss Prot	P49137
Scientific Background	MAPKAPK2 is a protein-serine/threonine kinase regulated through direct phosphorylation by p38 MAPK. It is involved in a number of cellular processes such as inflammation, stress responses, nuclear export, cell proliferation, and regulation of gene expression. It mediates both ERK and p38 MAPK-dependent neutrophil responses, participates in TNFα-stimulated exocytosis of secretory vesicles in neutrophils, and plays a role in phagocytosis-induced respiratory burst activity. Another one of its major substrates is HSP27, a protein responsble for stimulating actin polymerization in order to facilitate the recovery from cytoskeleton destruction during cellular stress. Over-expression of the gene has been linked to Multiple Myeloma resistance to chemotherapy, and it has been found to play a role in neuroinflammatory and neurodegenerative diseases such as Alzheimer's.

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R-PE (R-Phycoerythrin)

Overview:

Broad excitation spectrum
High quantum yield
Photostable
Member of the phycobiliprotein family
Isolated from red algae
Excellent solubility in water
Molecular Weight: 250 kDa

R-PE Datasheet

R-PE Fluorophore Excitation and Emission Spectra

Optical Properties:

λ_ex = 565 nm

λ_em = 575 nm

ε_max = 2.0×10⁶

Φ_f = 0.84

Brightness = 1.68 x 10³

Laser = 488 to 561 nm

Filter set = TRITC

品牌介绍

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。

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