StressMarq/Anti-MAPK11 Antibody/SPC-1179D-STR/100-µl-免疫在线蚂蚁淘旗下平台

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商品详细StressMarq/Anti-MAPK11 Antibody/SPC-1179D-STR/100-µl

StressMarq/Anti-MAPK11 Antibody/SPC-1179D-STR/100-µl

商品编号： SPC-1179D-STR

品牌： StressMarq Biosciences

市场价： ¥6800.00

美元价： 4080.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Overview:

ProductName MAPK11Antibody

Description

RabbitAnti-HumanMAPK11Polyclonal

SpeciesReactivity Human,Mouse

Applications WB,AM

AntibodyDilution WB(1:250);optimaldilutionsforassaysshouldbedeterminedbytheuser.

HostSpecies Rabbit

ImmunogenSpecies Human

Immunogen SyntheticpeptideofhumanMAPK11(AA320-334)

Conjugates

AlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBuffer	PBSpH7.4,50%glycerol,0.025%Thimerosal
StorageTemperature	-20ºC
ShippingTemperature	BlueIceor4ºC
Purification	PeptideAffinityPurified
Clonality	Polyclonal
Specificity	Detects41.357kDa.
CiteThisProduct	StressMarqBiosciencesCat#SPC-1179,RRID:AB_2711603
CertificateofAnalysis	A1:250dilutionofSPC-1179wassufficientfordetectionofMAPK11in10µgof293TcelllysatebyECLimmunoblotanalysisusinggoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNames	Humanp38BetaMAPkinasemRNAcompletecdsantibody,MAPkinase11antibody,MAPkinasep38betaantibody,MAPK11antibody,Mapk11antibody,Mitogenactivatedproteinkinase11antibody,Mitogenactivatedproteinkinasep382antibody,Mitogenactivatedproteinkinasep38betaantibody,Mitogen-activatedproteinkinase11antibody,Mitogen-activatedproteinkinasep38betaantibody,MK11_HUMANantibody,p382antibody,p38Bantibody,p38Betaantibody,PRKM11antibody,Proteinkinasemitogenactivated11antibody,SAPK2antibody,SAPK2Bantibody,Stressactivatedproteinkinase2antibody,Stressactivatedproteinkinase2bantibody
CellularLocalization	Cytoplasm,Nucleus
AccessionNumber	NP_002742
GeneID	5600
SwissProt	Q15759
ScientificBackground	Serine/threoninekinasewhichactsasanessentialcomponentoftheMAPkinasesignaltransductionpathway.MAPK11isoneofthefourp38MAPKswhichplayanimportantroleinthecascadesofcellularresponsesevokedbyextracellularstimulisuchasproinflammatorycytokinesorphysicalstressleADIngtodirectactivationoftranscriptionfactors.Accordingly,p38MAPKsphosphorylateabroadrangeofproteinsandithasbeenestimatedthattheymayhaveapproximately200to300substrateseach.MAPK11functionsaremostlyredundantwiththoseofMAPK14.Someofthetargetsaredownstreamkinaseswhichareactivatedthroughphosphorylationandfurtherphosphorylateadditionaltargets.RPS6KA5/MSK1andRPS6KA4/MSK2candirectlyphosphorylateandactivatetranscriptionfactorssuchasCREB1,ATF1,theNF-kappa-BisoformRELA/NFKB3,STAT1andSTAT3,butcanalsophosphorylatehistoneH3andthenucleosomalproteinHMGN1.RPS6KA5/MSK1andRPS6KA4/MSK2playimportantrolesintherapidinductionofimmediate-earlygenesinresponsetostressormitogenicstimuli,eitherbyinducingchromatinremodelingorbyrecruitingthetranscriptionmachinery.Ontheotherhand,twootherkinasetargets,MAPKAPK2/MK2andMAPKAPK3/MK3,participateinthecontrolofgeneexpressionmostlyatthepost-transcriptionallevel,byphosphorylatingZFP36(tristetraprolin)andELAVL1,andbyregulatingEEF2K,whichisimportantfortheelongationofmRNAduringtranslation.MKNK1/MNK1andMKNK2/MNK2,twootherkinasesactivatedbyp38MAPKs,regulateproteinsynthesisbyphosphorylatingtheinitiationfactorEIF4E2.Inthecytoplasm,thep38MAPKpathwayisanimportantregulatorofproteinturnover.Forexample,CFLARisaninhibitorofTNF-inducedapoptosiswhoseproteasome-mediateddegradationisregulatedbyp38MAPKphosphorylation.Ectodomainsheddingoftransmembraneproteinsisregulatedbyp38MAPKsaswell.Inresponsetoinflammatorystimuli,p38MAPKsphosphorylatethemembrane-associatedmetalloproteaseADAM17.SuchphosphorylationisrequiredforADAM17-mediatedectodomainsheddingofTGF-alphafamilyligands,whichresultsintheactivationofEGFRsignalingandcellproliferation.Additionalexamplesofp38MAPKsubstratesaretheFGFR1.FGFR1canbetranslocatedfromtheextracellularspaceintothecytosolandnucleusoftargetcells,andregulatesprocessessuchasrRNAsynthesisandcellgrowth.FGFR1translocationrequiresp38MAPKactivation.Inthenucleus,manytranscriptionfactorsarephosphorylatedandactivatedbyp38MAPKsinresponsetodifferentstimuli.ClassicalexamplesincludeATF1,ATF2,ATF6,ELK1,PTPRH,DDIT3,TP53/p53andMEF2CandMEF2A.Thep38MAPKsareemergingasimportantmodulatorsofgeneexpressionbyregulatingchromatinmodifiersandremodelers.Thepromotersofseveralgenesinvolvedintheinflammatoryresponse,suchasIL6,IL8andIL12B,displayap38MAPK-dependentenrichmentofhistoneH3phosphorylationon"Ser-10"(H3S10ph)inLPS-stimulatedmyeloidcells.ThisphosphorylationenhancestheaccessibilityofthecrypticNF-kappa-B-bindingsitesmarkingpromotersforincreasedNF-kappa-Brecruitment.

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Streptavidin

Properties:

Homo-tetramericproteinpurifiedfromStreptomycesavidiniiwhichbindsfourbiotinmoleculeswithextremelyhighaffinity
Molecularweight:53kDa
Formula:C₁₀H₁₆N₂O₃S
Applications:Westernblot,immunohistochemistry,andELISA

StreptavidinDatasheet

品牌介绍

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。

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